DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTETPQDT
Uniprot ID:
P30260
Source protein:
Cell division cycle protein 27 homolog
Source gene:
CDC27
Class:
DEG_SCF_FBW7_1
Location:
202:209
E3 ligase:
FBXW7
DEGRON score:
0.9915
ASA_SCORE:
91.8
COIL:
0.8414
CONS_SCORE:
0.2288
DSS_SCORE:
0.5228
HELIX:
0.1348
FCONS_SCORE:
1.0504
RIG_SCORE:
0.7634
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R214I
TCGA-AP-A059
UCEC
TCGA
LTETPQDT
DEG_SCF_FBW7_1
0.1944
p.R214I
DO41361
UCEC
ICGC
LTETPQDT
DEG_SCF_FBW7_1
0.1944
p.T203M
TCGA-VQ-A924
STAD
TCGA
LTETPQDT
DEG_SCF_FBW7_1
0.7423
p.T203M
DO51795
STAD
ICGC
LTETPQDT
DEG_SCF_FBW7_1
0.7423
p.S194C
DO228943
LICA
ICGC
LTETPQDT
DEG_SCF_FBW7_1
0.5556
p.S194C
DO229259
THCA
ICGC
LTETPQDT
DEG_SCF_FBW7_1
0.5556
p.S194C
DO229224
THCA
ICGC
LTETPQDT
DEG_SCF_FBW7_1
0.5556
p.S194C
DO229250
THCA
ICGC
LTETPQDT
DEG_SCF_FBW7_1
0.5556
p.L215W
DO229030
LICA
ICGC
LTETPQDT
DEG_SCF_FBW7_1
0.1667
p.L215W
DO229052
LICA
ICGC
LTETPQDT
DEG_SCF_FBW7_1
0.1667
p.R214G
DO229052
LICA
ICGC
LTETPQDT
DEG_SCF_FBW7_1
0.1944
p.T205I
DO229259
THCA
ICGC
LTETPQDT
DEG_SCF_FBW7_1
0.8189
p.D208Y
DO229272
THCA
ICGC
LTETPQDT
DEG_SCF_FBW7_1
0.6214
p.V201I
DO231401
THCA
ICGC
LTETPQDT
DEG_SCF_FBW7_1
0.3056
p.P206L
SIDM00454
Rhabdomyosarcoma
GDSC
LTETPQDT
DEG_SCF_FBW7_1
0.7582
p.P206L
ACH-000689
Sarcoma
CCLE
LTETPQDT
DEG_SCF_FBW7_1
0.7582
p.P206L
RH-18
soft_tissue
COSMIC
LTETPQDT
DEG_SCF_FBW7_1
0.7582
p.H195Y
SIDM00755
Non-Small Cell Lung Carcinoma
GDSC
LTETPQDT
DEG_SCF_FBW7_1
0.1389
p.H195Y
ACH-000888
Lung Cancer
CCLE
LTETPQDT
DEG_SCF_FBW7_1
0.1389
p.H195Y
NCI-H1793
lung
COSMIC
LTETPQDT
DEG_SCF_FBW7_1
0.1389
p.Q207K
SIDM00115
Head and Neck Carcinoma
GDSC
LTETPQDT
DEG_SCF_FBW7_1
0.5833
p.Q207K
ACH-002298
Head and Neck Cancer
CCLE
LTETPQDT
DEG_SCF_FBW7_1
0.5833
p.Q207K
PCI-6A
upper_aerodigestive_tract
COSMIC
LTETPQDT
DEG_SCF_FBW7_1
0.5833
p.S192C
SIDM00173
Head and Neck Carcinoma
GDSC
LTETPQDT
DEG_SCF_FBW7_1
0.5
p.S192C
ACH-000618
Head and Neck Cancer
CCLE
LTETPQDT
DEG_SCF_FBW7_1
0.5
p.E199Q
ACH-000923
Lymphoma
CCLE
LTETPQDT
DEG_SCF_FBW7_1
0.25
p.N213S
ACH-001846
Bile Duct Cancer
CCLE
LTETPQDT
DEG_SCF_FBW7_1
0.2222
Drug responses associated with CDC27 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTETPQDT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P30260
Cell division cycle protein 27 homolog
DEG_SCF_FBW7_1
202:209
LTETPQDT
FBXW7
0.9915
More...