DegronMD

Uniprot ID: P30260

Source protein: Cell division cycle protein 27 homolog

Source gene: CDC27

Class: DEG_SCF_FBW7_1

Location: 202:209

E3 ligase: FBXW7

DEGRON score: 0.9915

ASA_SCORE: 91.8

COIL: 0.8414

CONS_SCORE: 0.2288

DSS_SCORE: 0.5228

HELIX: 0.1348

FCONS_SCORE: 1.0504

RIG_SCORE: 0.7634

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T205I	DO229259	THCA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	0.8189
p.P206L	SIDM00454	Rhabdomyosarcoma	GDSC	LTETPQDT	DEG_SCF_FBW7_1	0.7582
p.P206L	ACH-000689	Sarcoma	CCLE	LTETPQDT	DEG_SCF_FBW7_1	0.7582
p.P206L	RH-18	soft_tissue	COSMIC	LTETPQDT	DEG_SCF_FBW7_1	0.7582
p.T203M	TCGA-VQ-A924	STAD	TCGA	LTETPQDT	DEG_SCF_FBW7_1	0.7423
p.T203M	DO51795	STAD	ICGC	LTETPQDT	DEG_SCF_FBW7_1	0.7423
p.D208Y	DO229272	THCA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	0.6214
p.Q207K	SIDM00115	Head and Neck Carcinoma	GDSC	LTETPQDT	DEG_SCF_FBW7_1	0.5833
p.Q207K	ACH-002298	Head and Neck Cancer	CCLE	LTETPQDT	DEG_SCF_FBW7_1	0.5833
p.Q207K	PCI-6A	upper_aerodigestive_tract	COSMIC	LTETPQDT	DEG_SCF_FBW7_1	0.5833
p.S194C	DO228943	LICA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	0.5556
p.S194C	DO229259	THCA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	0.5556
p.S194C	DO229224	THCA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	0.5556
p.S194C	DO229250	THCA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	0.5556
p.S192C	SIDM00173	Head and Neck Carcinoma	GDSC	LTETPQDT	DEG_SCF_FBW7_1	0.5
p.S192C	ACH-000618	Head and Neck Cancer	CCLE	LTETPQDT	DEG_SCF_FBW7_1	0.5
p.V201I	DO231401	THCA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	0.3056
p.E199Q	ACH-000923	Lymphoma	CCLE	LTETPQDT	DEG_SCF_FBW7_1	0.25
p.N213S	ACH-001846	Bile Duct Cancer	CCLE	LTETPQDT	DEG_SCF_FBW7_1	0.2222
p.R214I	TCGA-AP-A059	UCEC	TCGA	LTETPQDT	DEG_SCF_FBW7_1	0.1944
p.R214I	DO41361	UCEC	ICGC	LTETPQDT	DEG_SCF_FBW7_1	0.1944
p.R214G	DO229052	LICA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	0.1944
p.L215W	DO229030	LICA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	0.1667
p.L215W	DO229052	LICA	ICGC	LTETPQDT	DEG_SCF_FBW7_1	0.1667
p.H195Y	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	LTETPQDT	DEG_SCF_FBW7_1	0.1389

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Drug responses associated with CDC27 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LTETPQDT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30260	Cell division cycle protein 27 homolog	DEG_SCF_FBW7_1	202:209	LTETPQDT	FBXW7	0.9915	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTETPQDT

Degron related mutations and impact score

Drug responses associated with CDC27 mutations

All proteins holding degron of LTETPQDT