DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PGRTPAPS
Uniprot ID:
Q9NZM4
Source protein:
BRD4-interacting chromatin-remodeling complex-associated protein
Source gene:
BICRA
Class:
DEG_SCF_FBW7_1
Location:
1515:1522
E3 ligase:
FBXW7
DEGRON score:
0.8363
ASA_SCORE:
97.3375
COIL:
0.9695
CONS_SCORE:
0.3948
DSS_SCORE:
0.6855
HELIX:
0.011
FCONS_SCORE:
0.7781
RIG_SCORE:
0.5565
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D1506G
SIDM00537
Colorectal Carcinoma
GDSC
PGRTPAPS
DEG_SCF_FBW7_1
0.0833
p.D1506G
GP5d
large_intestine
COSMIC
PGRTPAPS
DEG_SCF_FBW7_1
0.0833
Drug responses associated with BICRA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PGRTPAPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NZM4
BRD4-interacting chromatin-remodeling complex-associated protein
DEG_SCF_FBW7_1
1515:1522
PGRTPAPS
FBXW7
0.8363
More...