DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PGRTPAPS
Uniprot ID:
Q9NZM4
Source protein:
BRD4-interacting chromatin-remodeling complex-associated protein
Source gene:
BICRA
Class:
DEG_SCF_FBW7_1
Location:
1515:1522
E3 ligase:
FBXW7
DEGRON score:
0.8363
ASA_SCORE:
97.3375
COIL:
0.9695
CONS_SCORE:
0.3948
DSS_SCORE:
0.6855
HELIX:
0.011
FCONS_SCORE:
0.7781
RIG_SCORE:
0.5565
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D1506G
SIDM00537
Colorectal Carcinoma
GDSC
PGRTPAPS
DEG_SCF_FBW7_1
0.0833
p.D1506G
GP5d
large_intestine
COSMIC
PGRTPAPS
DEG_SCF_FBW7_1
0.0833
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Drug responses associated with BICRA mutations
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Cancer
Mutation (In Degron?)
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Drug
IC50
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All proteins holding degron of PGRTPAPS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NZM4
BRD4-interacting chromatin-remodeling complex-associated protein
DEG_SCF_FBW7_1
1515:1522
PGRTPAPS
FBXW7
0.8363
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