DegronMD - P31645(SLC6A4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S44P	TCGA-66-2758	LUSC	TCGA	NGYSAVP	CBL_PTK	45:51	Mutation rewiring degron network	0.3056
p.S44P	DO26731	LUSC	ICGC	NGYSAVP	CBL_PTK	45:51	Mutation rewiring degron network	0.3056
p.S13L	TCGA-AC-A23H	BRCA	TCGA	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation blocking phosphorylation signal	0.6389
p.S13L	DO2401	BRCA	ICGC	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation blocking phosphorylation signal	0.6389
p.A55V	TCGA-AX-A2HA	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0833
p.A55V	TCGA-AX-A2HA	UCEC	TCGA	NGYSAVP	CBL_PTK	45:51	Mutation rewiring degron network	0.2222
p.A55V	DO233911	GACA	ICGC	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0833
p.A55V	DO233911	GACA	ICGC	NGYSAVP	CBL_PTK	45:51	Mutation rewiring degron network	0.2222
p.A55V	DO42504	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0833
p.A55V	DO42504	UCEC	ICGC	NGYSAVP	CBL_PTK	45:51	Mutation rewiring degron network	0.2222
p.S8Y	TCGA-B5-A0JY	UCEC	TCGA	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.712
p.S8Y	DO43041	UCEC	ICGC	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.712
p.S8Y	SIDM01007	T-Lymphoblastic Leukemia	GDSC	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.712
p.S8Y	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.712
p.A55T	TCGA-BR-7851	STAD	TCGA	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0833
p.A55T	TCGA-BR-7851	STAD	TCGA	NGYSAVP	CBL_PTK	45:51	Mutation rewiring degron network	0.2222
p.A55T	DO38711	STAD	ICGC	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0833
p.A55T	DO38711	STAD	ICGC	NGYSAVP	CBL_PTK	45:51	Mutation rewiring degron network	0.2222
p.Q9E	TCGA-CN-6013	HNSC	TCGA	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.3056
p.Q9E	DO15975	HNSC	ICGC	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.3056
p.L74R	TCGA-D8-A1XK	BRCA	TCGA	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1667
p.L74R	DO4749	BRCA	ICGC	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1667
p.S62F	TCGA-DX-A8BP	SARC	TCGA	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.2778
p.S62F	DO220056	SARC	ICGC	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.2778
p.D58N	TCGA-FR-A8YC	SKCM	TCGA	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1667
p.D58N	TCGA-FR-A8YC	SKCM	TCGA	NGYSAVP	CBL_PTK	45:51	Mutation rewiring degron network	0.1389
p.D58N	DO50301	SKCM	ICGC	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1667
p.D58N	DO50301	SKCM	ICGC	NGYSAVP	CBL_PTK	45:51	Mutation rewiring degron network	0.1389
p.Q76E	TCGA-SY-A9G5	BLCA	TCGA	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1111
p.Q76E	DO51906	BLCA	ICGC	PATTT	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.1111
p.T3M	TCGA-XK-AAIW	PRAD	TCGA	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.6312
p.T3M	DO51407	PRAD	ICGC	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.6312
p.Q42K	DO1018	BRCA	ICGC	NGYSAVP	CBL_PTK	45:51	Mutation rewiring degron network	0.25
p.S52R	DO50869	LICA	ICGC	NGYSAVP	CBL_PTK	45:51	Mutation rewiring degron network	0.3056
p.T4M	DO33432	PACA	ICGC	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.7423
p.T67A	DO51187	PAEN	ICGC	PATTT	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.7139
p.N45S	SIDM00281	Other Solid Cancers	GDSC	NGYSAVP	CBL_PTK	45:51	Mutation altering degron motif	0.7069
p.N45S	SIDM01210	Glioblastoma	GDSC	NGYSAVP	CBL_PTK	45:51	Mutation altering degron motif	0.7069
p.N45S	ACH-000479	Brain Cancer	CCLE	NGYSAVP	CBL_PTK	45:51	Mutation altering degron motif	0.7069
p.N45S	ACH-002100	Skin Cancer	CCLE	NGYSAVP	CBL_PTK	45:51	Mutation altering degron motif	0.7069
p.N45S	ACH-002259	Brain Cancer	CCLE	NGYSAVP	CBL_PTK	45:51	Mutation altering degron motif	0.7069
p.N45S	DJM-1	skin	COSMIC	NGYSAVP	CBL_PTK	45:51	Mutation altering degron motif	0.7069
p.N45S	KNS-81-FD	central nervous system	COSMIC	NGYSAVP	CBL_PTK	45:51	Mutation altering degron motif	0.7069
p.S48L	SIDM00092	Ovarian Carcinoma	GDSC	NGYSAVP	CBL_PTK	45:51	Mutation altering degron motif	0.8778
p.S48L	ACH-000617	Ovarian Cancer	CCLE	NGYSAVP	CBL_PTK	45:51	Mutation altering degron motif	0.8778
p.S48L	OVCAR-4	ovary	COSMIC	NGYSAVP	CBL_PTK	45:51	Mutation altering degron motif	0.8778
p.A14V	SIDM00282	Colorectal Carcinoma	GDSC	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.1667
p.A14V	ACH-000998	Colon/Colorectal Cancer	CCLE	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.1667
p.A14V	CW-2	large intestine	COSMIC	METTPLNS	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.1667
p.G41R	SIDM00024	Non-Cancerous	GDSC	NGYSAVP	CBL_PTK	45:51	Mutation rewiring degron network	0.2222
p.V50L	ACH-001982	Metastasis	CCLE	NGYSAVP	CBL_PTK	45:51	Mutation altering degron motif	0.5654

Kaplan plot for SLC6A4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC6A4

UniProt ID: P31645

Entrez ID: 6532

Protein name: Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC6A4 in