DegronMD

Uniprot ID: P31645

Source protein: Sodium-dependent serotonin transporter

Source gene: SLC6A4

Class: DEG_SCF_FBW7_1

Location: 1:8

E3 ligase: FBXW7

DEGRON score: 0.9788

ASA_SCORE: 112.075

COIL: 0.8755

CONS_SCORE: 0.2398

DSS_SCORE: 0.8394

HELIX: 0.1113

FCONS_SCORE: 1.0229

RIG_SCORE: 0.7125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S13L	TCGA-AC-A23H	BRCA	TCGA	METTPLNS	DEG_SCF_FBW7_1	0.6389
p.S13L	DO2401	BRCA	ICGC	METTPLNS	DEG_SCF_FBW7_1	0.6389
p.S8Y	TCGA-B5-A0JY	UCEC	TCGA	METTPLNS	DEG_SCF_FBW7_1	0.712
p.S8Y	DO43041	UCEC	ICGC	METTPLNS	DEG_SCF_FBW7_1	0.712
p.S8Y	SIDM01007	T-Lymphoblastic Leukemia	GDSC	METTPLNS	DEG_SCF_FBW7_1	0.712
p.S8Y	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	METTPLNS	DEG_SCF_FBW7_1	0.712
p.Q9E	TCGA-CN-6013	HNSC	TCGA	METTPLNS	DEG_SCF_FBW7_1	0.3056
p.Q9E	DO15975	HNSC	ICGC	METTPLNS	DEG_SCF_FBW7_1	0.3056
p.T3M	TCGA-XK-AAIW	PRAD	TCGA	METTPLNS	DEG_SCF_FBW7_1	0.6312
p.T3M	DO51407	PRAD	ICGC	METTPLNS	DEG_SCF_FBW7_1	0.6312
p.T4M	DO33432	PACA	ICGC	METTPLNS	DEG_SCF_FBW7_1	0.7423
p.A14V	SIDM00282	Colorectal Carcinoma	GDSC	METTPLNS	DEG_SCF_FBW7_1	0.1667
p.A14V	ACH-000998	Colon/Colorectal Cancer	CCLE	METTPLNS	DEG_SCF_FBW7_1	0.1667
p.A14V	CW-2	large_intestine	COSMIC	METTPLNS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31645	Sodium-dependent serotonin transporter	DEG_SCF_FBW7_1	1:8	METTPLNS	FBXW7	0.9788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons