DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NGYSAVP
Uniprot ID:
P31645
Source protein:
Sodium-dependent serotonin transporter
Source gene:
SLC6A4
Class:
CBL_PTK
Location:
45:51
E3 ligase:
CBL
DEGRON score:
0.9982
ASA_SCORE:
81.8429
COIL:
0.9184
CONS_SCORE:
0.2464
DSS_SCORE:
0.6378
HELIX:
0.023
FCONS_SCORE:
1.0712
RIG_SCORE:
0.6457
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S44P
TCGA-66-2758
LUSC
TCGA
NGYSAVP
CBL_PTK
0.3056
p.S44P
DO26731
LUSC
ICGC
NGYSAVP
CBL_PTK
0.3056
p.A55V
TCGA-AX-A2HA
UCEC
TCGA
NGYSAVP
CBL_PTK
0.2222
p.A55V
DO233911
GACA
ICGC
NGYSAVP
CBL_PTK
0.2222
p.A55V
DO42504
UCEC
ICGC
NGYSAVP
CBL_PTK
0.2222
p.A55T
TCGA-BR-7851
STAD
TCGA
NGYSAVP
CBL_PTK
0.2222
p.A55T
DO38711
STAD
ICGC
NGYSAVP
CBL_PTK
0.2222
p.D58N
TCGA-FR-A8YC
SKCM
TCGA
NGYSAVP
CBL_PTK
0.1389
p.D58N
DO50301
SKCM
ICGC
NGYSAVP
CBL_PTK
0.1389
p.Q42K
DO1018
BRCA
ICGC
NGYSAVP
CBL_PTK
0.25
p.S52R
DO50869
LICA
ICGC
NGYSAVP
CBL_PTK
0.3056
p.N45S
SIDM00281
Other Solid Cancers
GDSC
NGYSAVP
CBL_PTK
0.7069
p.N45S
SIDM01210
Glioblastoma
GDSC
NGYSAVP
CBL_PTK
0.7069
p.N45S
ACH-000479
Brain Cancer
CCLE
NGYSAVP
CBL_PTK
0.7069
p.N45S
ACH-002100
Skin Cancer
CCLE
NGYSAVP
CBL_PTK
0.7069
p.N45S
ACH-002259
Brain Cancer
CCLE
NGYSAVP
CBL_PTK
0.7069
p.N45S
DJM-1
skin
COSMIC
NGYSAVP
CBL_PTK
0.7069
p.N45S
KNS-81-FD
central_nervous_system
COSMIC
NGYSAVP
CBL_PTK
0.7069
p.S48L
SIDM00092
Ovarian Carcinoma
GDSC
NGYSAVP
CBL_PTK
0.8778
p.S48L
ACH-000617
Ovarian Cancer
CCLE
NGYSAVP
CBL_PTK
0.8778
p.S48L
OVCAR-4
ovary
COSMIC
NGYSAVP
CBL_PTK
0.8778
p.G41R
SIDM00024
Non-Cancerous
GDSC
NGYSAVP
CBL_PTK
0.2222
p.V50L
ACH-001982
Metastasis
CCLE
NGYSAVP
CBL_PTK
0.5654
Drug responses associated with SLC6A4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NGYSAVP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P31645
Sodium-dependent serotonin transporter
CBL_PTK
45:51
NGYSAVP
CBL
0.9982
More...