DegronMD

Uniprot ID: P31645

Source protein: Sodium-dependent serotonin transporter

Source gene: SLC6A4

Class: DEG_SPOP_SBC_1

Location: 64:68

E3 ligase: SPOP

DEGRON score: 0.7561

ASA_SCORE: 90.2

COIL: 0.8954

CONS_SCORE: 0.2532

DSS_SCORE: 0.5007

HELIX: 0.0896

FCONS_SCORE: 1.024

RIG_SCORE: 0.7612

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A55V	TCGA-AX-A2HA	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	0.0833
p.A55V	DO233911	GACA	ICGC	PATTT	DEG_SPOP_SBC_1	0.0833
p.A55V	DO42504	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	0.0833
p.A55T	TCGA-BR-7851	STAD	TCGA	PATTT	DEG_SPOP_SBC_1	0.0833
p.A55T	DO38711	STAD	ICGC	PATTT	DEG_SPOP_SBC_1	0.0833
p.L74R	TCGA-D8-A1XK	BRCA	TCGA	PATTT	DEG_SPOP_SBC_1	0.1667
p.L74R	DO4749	BRCA	ICGC	PATTT	DEG_SPOP_SBC_1	0.1667
p.S62F	TCGA-DX-A8BP	SARC	TCGA	PATTT	DEG_SPOP_SBC_1	0.2778
p.S62F	DO220056	SARC	ICGC	PATTT	DEG_SPOP_SBC_1	0.2778
p.D58N	TCGA-FR-A8YC	SKCM	TCGA	PATTT	DEG_SPOP_SBC_1	0.1667
p.D58N	DO50301	SKCM	ICGC	PATTT	DEG_SPOP_SBC_1	0.1667
p.Q76E	TCGA-SY-A9G5	BLCA	TCGA	PATTT	DEG_SPOP_SBC_1	0.1111
p.Q76E	DO51906	BLCA	ICGC	PATTT	DEG_SPOP_SBC_1	0.1111
p.T67A	DO51187	PAEN	ICGC	PATTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	311:315	PATTT	SPOP	0.8955	More...
P31645	Sodium-dependent serotonin transporter	DEG_SPOP_SBC_1	64:68	PATTT	SPOP	0.7561	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_SPOP_SBC_1	564:568	PATTT	SPOP	0.9146	More...
Q03001	Dystonin	DEG_SPOP_SBC_1	7436:7440	PATTT	SPOP	0.9065	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	498:502	PATTT	SPOP	0.9968	More...
Q6EMK4	Vasorin	DEG_SPOP_SBC_1	350:354	PATTT	SPOP	0.9976	More...
Q6ISU1	Pre T-cell antigen receptor alpha	DEG_SPOP_SBC_1	182:186	PATTT	SPOP	0.9264	More...
Q765P7	Protein MTSS 2	DEG_SPOP_SBC_1	313:317	PATTT	SPOP	0.6279	More...
Q86UK7	E3 ubiquitin-protein ligase ZNF598	DEG_SPOP_SBC_1	729:733	PATTT	SPOP	0.9959	More...
Q8N3V7	Synaptopodin	DEG_SPOP_SBC_1	407:411	PATTT	SPOP	0.998	More...
Q8N9I0	Synaptotagmin-2	DEG_SPOP_SBC_1	15:19	PATTT	SPOP	0.7121	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1537:1541	PATTT	SPOP	0.9939	More...
Q8TAQ2	SWI/SNF complex subunit SMARCC2	DEG_SPOP_SBC_1	1148:1152	PATTT	SPOP	0.9655	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7725:7729	PATTT	SPOP	0.9548	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	62:66	PATTT	SPOP	0.9768	More...
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	DEG_SPOP_SBC_1	879:883	PATTT	SPOP	0.9977	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	695:699	PATTT	SPOP	0.9941	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	1042:1046	PATTT	SPOP	0.8197	More...
Q9H8Y8	Golgi reassembly-stacking protein 2	DEG_SPOP_SBC_1	397:401	PATTT	SPOP	0.999	More...
Q9NYI0	PH and SEC7 domain-containing protein 3	DEG_SPOP_SBC_1	921:925	PATTT	SPOP	0.9983	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	428:432	PATTT	SPOP	0.947	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_SPOP_SBC_1	78:82	PATTT	SPOP	0.9893	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2539:2543	PATTT	SPOP	0.77	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	1824:1828	PATTT	SPOP	0.9363	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	220:224	PATTT	SPOP	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATTT

Degron related mutations and impact score

Drug responses associated with SLC6A4 mutations

All proteins holding degron of PATTT