DegronMD - O43670(ZNF207)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S325N	TCGA-AP-A059	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.0556
p.S325N	TCGA-AP-A059	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1944
p.A306S	TCGA-AX-A06F	UCEC	TCGA	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation rewiring degron network	0.3056
p.A306S	TCGA-AX-A06F	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.1944
p.T329K	TCGA-B0-5701	KIRC	TCGA	ASTTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.3056
p.P272H	TCGA-BF-A1Q0	SKCM	TCGA	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.1944
p.P272H	TCGA-BF-A1Q0	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.2222
p.T256S	TCGA-BR-6452	STAD	TCGA	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.1944
p.T256S	TCGA-BR-6452	STAD	TCGA	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1111
p.P327T	TCGA-DA-A1I7	SKCM	TCGA	ASTTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.25
p.A123T	TCGA-EL-A3CM	THCA	TCGA	AASTS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6028
p.A123T	DO23543	LIRI	ICGC	AASTS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6028
p.A123T	DO40173	THCA	ICGC	AASTS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6028
p.Q133K	TCGA-EL-A3MY	THCA	TCGA	AASTS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.Q133K	DO39610	THCA	ICGC	AASTS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.D114N	TCGA-KQ-A41R	BLCA	TCGA	AASTS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1111
p.D114N	DO223592	BLCA	ICGC	AASTS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1111
p.S121C	TCGA-LC-A66R	BLCA	TCGA	AASTS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.3056
p.S121C	DO44031	BLCA	ICGC	AASTS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.3056
p.D120N	TCGA-YD-A9TA	SKCM	TCGA	AASTS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2778
p.D120N	DO219503	SKCM	ICGC	AASTS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2778
p.Y325H	DO225249	BRCA	ICGC	PATTT	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.0556
p.Y325H	DO225249	BRCA	ICGC	ASTTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1944
p.V300L	DO228345	BRCA	ICGC	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation rewiring degron network	0.1389
p.V265I	DO223936	BRCA	ICGC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation altering degron motif	0.5965
p.V265I	DO223936	BRCA	ICGC	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation altering degron motif	0.5965
p.S267R	DO9074	COAD	ICGC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation altering degron motif	0.7427
p.S267R	DO9074	COAD	ICGC	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation altering degron motif	0.7427
p.D117N	DO234353	ESAD	ICGC	AASTS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1944
p.D114G	DO233623	GACA	ICGC	AASTS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1111
p.A340T	DO233884	GACA	ICGC	ASTTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1667
p.A271V	DO10880	GBM	ICGC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.2222
p.A271V	DO10880	GBM	ICGC	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.25
p.E115K	DO15398	HNSC	ICGC	AASTS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.T313K	DO16240	KIRC	ICGC	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation altering degron motif	0.6195
p.T313K	DO16240	KIRC	ICGC	PATTT	DEG_SPOP_SBC_1	311:315	Mutation altering degron motif	0.7306
p.A344S	DO22237	LGG	ICGC	ASTTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0556
p.Q327H	DO229019	LICA	ICGC	ASTTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.25
p.A312S	DO229036	LICA	ICGC	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation altering degron motif	0.6477
p.A312S	DO229036	LICA	ICGC	PATTT	DEG_SPOP_SBC_1	311:315	Mutation altering degron motif	0.6477
p.P255S	DO229058	LICA	ICGC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.1667
p.P255S	DO229058	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.0833
p.S272L	DO45251	LIRI	ICGC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.1944
p.S272L	DO45251	LIRI	ICGC	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.2222
p.F304L	DO222843	MELA	ICGC	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation rewiring degron network	0.25
p.F304L	DO222843	MELA	ICGC	PATTT	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.1389
p.P311T	DO37951	SKCM	ICGC	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation altering degron motif	0.7031
p.P311T	DO37951	SKCM	ICGC	PATTT	DEG_SPOP_SBC_1	311:315	Mutation altering degron motif	0.7031
p.P256H	DO47374	SKCM	ICGC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.1944
p.P256H	DO47374	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1111
p.S309N	DO41361	UCEC	ICGC	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation altering degron motif	0.5958
p.T258A	SIDM00845	Burkitt's Lymphoma	GDSC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.25
p.T258A	SIDM00845	Burkitt's Lymphoma	GDSC	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1667
p.T258A	SIDM01519	Head and Neck Carcinoma	GDSC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.25
p.T258A	SIDM01519	Head and Neck Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1667
p.T258A	ACH-000786	Lymphoma	CCLE	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.25
p.T258A	ACH-000786	Lymphoma	CCLE	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1667
p.T258A	Daudi	haematopoietic and lymphoid tissue	COSMIC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.25
p.T258A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1667
p.A310T	SIDM00054	Pancreatic Carcinoma	GDSC	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation altering degron motif	0.7139
p.A310T	ACH-001619	Gallbladder Cancer	CCLE	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation altering degron motif	0.7139
p.A310T	ACH-002185	Pancreatic Cancer	CCLE	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation altering degron motif	0.7139
p.A310T	PL18	pancreas	COSMIC	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation altering degron motif	0.7139
p.P260S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.3056
p.P260S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.2222
p.P260S	ACH-002222	Leukemia	CCLE	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.3056
p.P260S	ACH-002222	Leukemia	CCLE	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.2222
p.P260S	CTV-1	haematopoietic and lymphoid tissue	COSMIC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation rewiring degron network	0.3056
p.P260S	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.2222
p.P262T	SIDM00503	Gastric Carcinoma	GDSC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation altering degron motif	0.7031
p.P262T	ACH-000633	Gastric Cancer	CCLE	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation altering degron motif	0.7031
p.P262T	FU97	stomach	COSMIC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation altering degron motif	0.7031
p.S304N	SIDM00153	T-Lymphoblastic Leukemia	GDSC	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation rewiring degron network	0.25
p.S304N	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PATTT	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.1389
p.S304N	ACH-000964	Leukemia	CCLE	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation rewiring degron network	0.25
p.S304N	ACH-000964	Leukemia	CCLE	PATTT	DEG_SPOP_SBC_1	311:315	Mutation rewiring degron network	0.1389
p.A313T	PL18	pancreas	COSMIC	LNSTPATT	DEG_SCF_FBW7_1	307:314	Mutation altering degron motif	0.7139
p.A313T	PL18	pancreas	COSMIC	PATTT	DEG_SPOP_SBC_1	311:315	Mutation altering degron motif	0.7139
p.P263S	CTV-1	haematopoietic and lymphoid tissue	COSMIC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation altering degron motif	0.6752
p.T261A	Daudi	haematopoietic and lymphoid tissue	COSMIC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation altering degron motif	0.7139
p.P343Q	TE-5	oesophagus	COSMIC	ASTTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0833
p.P265T	FU97	stomach	COSMIC	MGTPVTS	DEG_SCF_FBW7_1	261:267	Mutation altering degron motif	0.7031
p.P265T	FU97	stomach	COSMIC	PVTSS	DEG_SPOP_SBC_1	264:268	Mutation altering degron motif	0.7031
p.P328Q	TE-5	oesophagus	COSMIC	ASTTS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF207

UniProt ID: O43670

Entrez ID: 7756

Protein name: BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF207 in