DegronMD

Uniprot ID: O43670

Source protein: BUB3-interacting and GLEBS motif-containing protein ZNF207

Source gene: ZNF207

Class: DEG_SCF_FBW7_1

Location: 261:267

E3 ligase: FBXW7

DEGRON score: 0.9911

ASA_SCORE: 75.9714

COIL: 0.92

CONS_SCORE: 0.1932

DSS_SCORE: 0.6025

HELIX: 0.0207

FCONS_SCORE: 0.7447

RIG_SCORE: 0.6232

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P272H	TCGA-BF-A1Q0	SKCM	TCGA	MGTPVTS	DEG_SCF_FBW7_1	0.1944
p.T256S	TCGA-BR-6452	STAD	TCGA	MGTPVTS	DEG_SCF_FBW7_1	0.1944
p.V265I	DO223936	BRCA	ICGC	MGTPVTS	DEG_SCF_FBW7_1	0.5965
p.S267R	DO9074	COAD	ICGC	MGTPVTS	DEG_SCF_FBW7_1	0.7427
p.A271V	DO10880	GBM	ICGC	MGTPVTS	DEG_SCF_FBW7_1	0.2222
p.P255S	DO229058	LICA	ICGC	MGTPVTS	DEG_SCF_FBW7_1	0.1667
p.S272L	DO45251	LIRI	ICGC	MGTPVTS	DEG_SCF_FBW7_1	0.1944
p.P256H	DO47374	SKCM	ICGC	MGTPVTS	DEG_SCF_FBW7_1	0.1944
p.T258A	SIDM00845	Burkitt's Lymphoma	GDSC	MGTPVTS	DEG_SCF_FBW7_1	0.25
p.T258A	SIDM01519	Head and Neck Carcinoma	GDSC	MGTPVTS	DEG_SCF_FBW7_1	0.25
p.T258A	ACH-000786	Lymphoma	CCLE	MGTPVTS	DEG_SCF_FBW7_1	0.25
p.T258A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	MGTPVTS	DEG_SCF_FBW7_1	0.25
p.P260S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	MGTPVTS	DEG_SCF_FBW7_1	0.3056
p.P260S	ACH-002222	Leukemia	CCLE	MGTPVTS	DEG_SCF_FBW7_1	0.3056
p.P260S	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	MGTPVTS	DEG_SCF_FBW7_1	0.3056
p.P262T	SIDM00503	Gastric Carcinoma	GDSC	MGTPVTS	DEG_SCF_FBW7_1	0.7031
p.P262T	ACH-000633	Gastric Cancer	CCLE	MGTPVTS	DEG_SCF_FBW7_1	0.7031
p.P262T	FU97	stomach	COSMIC	MGTPVTS	DEG_SCF_FBW7_1	0.7031
p.P263S	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	MGTPVTS	DEG_SCF_FBW7_1	0.6752
p.T261A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	MGTPVTS	DEG_SCF_FBW7_1	0.7139
p.P265T	FU97	stomach	COSMIC	MGTPVTS	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SCF_FBW7_1	261:267	MGTPVTS	FBXW7	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons