DegronMD

Uniprot ID: O43670

Source protein: BUB3-interacting and GLEBS motif-containing protein ZNF207

Source gene: ZNF207

Class: DEG_SCF_FBW7_1

Location: 307:314

E3 ligase: FBXW7

DEGRON score: 0.8896

ASA_SCORE: 88.9375

COIL: 0.9515

CONS_SCORE: 0.2562

DSS_SCORE: 0.6857

HELIX: 0.0176

FCONS_SCORE: 0.8307

RIG_SCORE: 0.6402

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A306S	TCGA-AX-A06F	UCEC	TCGA	LNSTPATT	DEG_SCF_FBW7_1	0.3056
p.V300L	DO228345	BRCA	ICGC	LNSTPATT	DEG_SCF_FBW7_1	0.1389
p.T313K	DO16240	KIRC	ICGC	LNSTPATT	DEG_SCF_FBW7_1	0.6195
p.A312S	DO229036	LICA	ICGC	LNSTPATT	DEG_SCF_FBW7_1	0.6477
p.F304L	DO222843	MELA	ICGC	LNSTPATT	DEG_SCF_FBW7_1	0.25
p.P311T	DO37951	SKCM	ICGC	LNSTPATT	DEG_SCF_FBW7_1	0.7031
p.S309N	DO41361	UCEC	ICGC	LNSTPATT	DEG_SCF_FBW7_1	0.5958
p.A310T	SIDM00054	Pancreatic Carcinoma	GDSC	LNSTPATT	DEG_SCF_FBW7_1	0.7139
p.A310T	ACH-001619	Gallbladder Cancer	CCLE	LNSTPATT	DEG_SCF_FBW7_1	0.7139
p.A310T	ACH-002185	Pancreatic Cancer	CCLE	LNSTPATT	DEG_SCF_FBW7_1	0.7139
p.A310T	PL18	pancreas	COSMIC	LNSTPATT	DEG_SCF_FBW7_1	0.7139
p.S304N	SIDM00153	T-Lymphoblastic Leukemia	GDSC	LNSTPATT	DEG_SCF_FBW7_1	0.25
p.S304N	ACH-000964	Leukemia	CCLE	LNSTPATT	DEG_SCF_FBW7_1	0.25
p.A313T	PL18	pancreas	COSMIC	LNSTPATT	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SCF_FBW7_1	307:314	LNSTPATT	FBXW7	0.8896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons