DegronMD - Q9H3S7(PTPN23)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1070Q	TCGA-21-1071	LUSC	TCGA	STPSPHLVPSP	DEG_COP1_1	1078:1088	Mutation rewiring degron network	0.1111
p.R1070Q	DO228879	LICA	ICGC	STPSPHLVPSP	DEG_COP1_1	1078:1088	Mutation rewiring degron network	0.1111
p.A539P	TCGA-2G-AAG9	TGCT	TCGA	LPTPALS	DEG_SCF_FBW7_1	540:546	Mutation rewiring degron network	0.3056
p.P1530Q	TCGA-55-6981	LUAD	TCGA	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1944
p.P1530Q	DO24265	LUAD	ICGC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1944
p.P1546T	TCGA-AA-3492	COAD	TCGA	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.P1546T	TCGA-AA-A01R	COAD	TCGA	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.P1546T	TCGA-BG-A3EW	UCEC	TCGA	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.P1546T	TCGA-EI-6882	READ	TCGA	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.P1546T	DO7934	COAD	ICGC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.P1546T	DO8224	COAD	ICGC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.P1546T	DO36531	READ	ICGC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.P1546T	DO48172	UCEC	ICGC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.P1546T	SIDM00945	Colorectal Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.P1546T	SIDM00282	Colorectal Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.R537W	TCGA-AN-A0AK	BRCA	TCGA	LPTPALS	DEG_SCF_FBW7_1	540:546	Mutation rewiring degron network	0.25
p.A426T	TCGA-AX-A0J1	UCEC	TCGA	DNLDAYSHIP	CBL_PTK	409:418	Mutation rewiring degron network	0.1111
p.A544T	TCGA-AX-A2HC	UCEC	TCGA	LPTPALS	DEG_SCF_FBW7_1	540:546	Mutation altering degron motif	0.6028
p.S400A	TCGA-B5-A1MR	UCEC	TCGA	DNLDAYSHIP	CBL_PTK	409:418	Mutation rewiring degron network	0.0833
p.A539T	TCGA-BR-7851	STAD	TCGA	LPTPALS	DEG_SCF_FBW7_1	540:546	Mutation rewiring degron network	0.3056
p.L1577M	TCGA-CV-6953	HNSC	TCGA	EEPPVPEA	DEG_COP1_1	1560:1567	Mutation rewiring degron network	0.0556
p.L1577M	TCGA-CV-6953	HNSC	TCGA	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation rewiring degron network	0.3056
p.L1577M	DO14278	HNSC	ICGC	EEPPVPEA	DEG_COP1_1	1560:1567	Mutation rewiring degron network	0.0556
p.L1577M	DO14278	HNSC	ICGC	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation rewiring degron network	0.3056
p.A1567V	TCGA-D1-A15X	UCEC	TCGA	EEPPVPEA	DEG_COP1_1	1560:1567	Mutation altering degron motif	0.5825
p.A1567V	DO43274	UCEC	ICGC	EEPPVPEA	DEG_COP1_1	1560:1567	Mutation altering degron motif	0.5825
p.S1576P	TCGA-D5-6930	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation altering degron motif	0.6752
p.S1576P	DO10550	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation altering degron motif	0.6752
p.A413T	TCGA-EE-A2MQ	SKCM	TCGA	DNLDAYSHIP	CBL_PTK	409:418	Mutation altering degron motif	0.6028
p.A413T	DO38711	STAD	ICGC	DNLDAYSHIP	CBL_PTK	409:418	Mutation altering degron motif	0.6028
p.R537L	TCGA-GN-A262	SKCM	TCGA	LPTPALS	DEG_SCF_FBW7_1	540:546	Mutation rewiring degron network	0.25
p.P1572A	TCGA-HF-7132	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation altering degron motif	0.6392
p.P1572A	DO38214	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation altering degron motif	0.6392
p.P1585T	TCGA-IB-7651	PAAD	TCGA	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation rewiring degron network	0.0833
p.P1585T	DO46657	PAAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation rewiring degron network	0.0833
p.L1548I	TCGA-OR-A5JA	ACC	TCGA	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1667
p.Q554P	TCGA-VQ-AA6F	STAD	TCGA	LPTPALS	DEG_SCF_FBW7_1	540:546	Mutation rewiring degron network	0.1111
p.R411W	DO1608	BRCA	ICGC	DNLDAYSHIP	CBL_PTK	409:418	Mutation altering degron motif	0.8634
p.E537K	DO2401	BRCA	ICGC	LPTPALS	DEG_SCF_FBW7_1	540:546	Mutation rewiring degron network	0.25
p.A538P	DO5752	BRCA	ICGC	LPTPALS	DEG_SCF_FBW7_1	540:546	Mutation rewiring degron network	0.2778
p.R401C	DO223732	CESC	ICGC	DNLDAYSHIP	CBL_PTK	409:418	Mutation rewiring degron network	0.1111
p.R401C	DO41903	UCEC	ICGC	DNLDAYSHIP	CBL_PTK	409:418	Mutation rewiring degron network	0.1111
p.R401H	DO8490	COAD	ICGC	DNLDAYSHIP	CBL_PTK	409:418	Mutation rewiring degron network	0.1111
p.P417L	DO233270	GACA	ICGC	DNLDAYSHIP	CBL_PTK	409:418	Mutation altering degron motif	0.7582
p.A1581V	DO233871	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation rewiring degron network	0.1944
p.P884R	DO48489	KIRP	ICGC	PATTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.3056
p.K424N	DO229018	LICA	ICGC	DNLDAYSHIP	CBL_PTK	409:418	Mutation substituting flanking lysine	0.2778
p.L1552P	DO50741	LICA	ICGC	EEPPVPEA	DEG_COP1_1	1560:1567	Mutation rewiring degron network	0.1111
p.L1552P	DO50741	LICA	ICGC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.0556
p.K544T	DO50931	LICA	ICGC	LPTPALS	DEG_SCF_FBW7_1	540:546	Mutation altering degron motif	0.7306
p.Q883P	DO228271	MALY	ICGC	PATTT	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7035
p.S1569R	DO228355	MALY	ICGC	EEPPVPEA	DEG_COP1_1	1560:1567	Mutation rewiring degron network	0.2778
p.S1569R	DO228355	MALY	ICGC	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation rewiring degron network	0.25
p.E1578K	DO220861	MELA	ICGC	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation rewiring degron network	0.2778
p.P1558L	DO222557	MELA	ICGC	EEPPVPEA	DEG_COP1_1	1560:1567	Mutation rewiring degron network	0.2778
p.R550K	DO227538	ORCA	ICGC	LPTPALS	DEG_SCF_FBW7_1	540:546	Mutation blocking ubiquitination signal	0.6667
p.R411L	DO37515	SKCM	ICGC	DNLDAYSHIP	CBL_PTK	409:418	Mutation altering degron motif	0.8428
p.Q428P	DO222393	STAD	ICGC	DNLDAYSHIP	CBL_PTK	409:418	Mutation rewiring degron network	0.0556
p.A418T	DO229242	THCA	ICGC	DNLDAYSHIP	CBL_PTK	409:418	Mutation altering degron motif	0.7139
p.A418T	DO41572	UCEC	ICGC	DNLDAYSHIP	CBL_PTK	409:418	Mutation altering degron motif	0.7139
p.Q877H	DO40802	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.S1542F	DO42304	UCEC	ICGC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation altering degron motif	0.9093
p.P1096L	SIDM01943	Colorectal Carcinoma	GDSC	STPSPHLVPSP	DEG_COP1_1	1078:1088	Mutation rewiring degron network	0.1111
p.P1531S	SIDM00373	Endometrial Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.P1531S	ACH-000974	Endometrial/Uterine Cancer	CCLE	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.P1531S	ACH-002026	Endometrial/Uterine Cancer	CCLE	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.P1531S	SNG-M	endometrium	COSMIC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.2222
p.L421R	SIDM01090	Colorectal Carcinoma	GDSC	DNLDAYSHIP	CBL_PTK	409:418	Mutation rewiring degron network	0.25
p.L421R	ACH-000943	Colon/Colorectal Cancer	CCLE	DNLDAYSHIP	CBL_PTK	409:418	Mutation rewiring degron network	0.25
p.L421R	RKO	large intestine	COSMIC	DNLDAYSHIP	CBL_PTK	409:418	Mutation rewiring degron network	0.25
p.P543L	SIDM00654	Small Cell Lung Carcinoma	GDSC	LPTPALS	DEG_SCF_FBW7_1	540:546	Mutation altering degron motif	0.7582
p.P543L	SIDM00793	Burkitt's Lymphoma	GDSC	LPTPALS	DEG_SCF_FBW7_1	540:546	Mutation altering degron motif	0.7582
p.P1547T	SIDM00630	Breast Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1944
p.P1547T	ACH-000876	Breast Cancer	CCLE	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1944
p.P1547T	MDA-MB-415	breast	COSMIC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1944
p.R878Q	SIDM00286	Neuroblastoma	GDSC	PATTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.3056
p.P1526T	SIDM00928	Breast Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.0833
p.P1526T	CAL-85-1	breast	COSMIC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.0833
p.P1530S	SIDM00772	Breast Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1944
p.P1530S	ACH-000755	Breast Cancer	CCLE	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1944
p.P1530S	HCC2218	breast	COSMIC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1944
p.G1528D	SIDM00251	Gastric Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1389
p.G1528D	ACH-000949	Gastric Cancer	CCLE	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1389
p.G1528D	TGBC11TKB	stomach	COSMIC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1389
p.P1547R	SIDM00858	Osteosarcoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1944
p.P1547R	G-292_Clone_A141B1	bone	COSMIC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.1944
p.P1573S	SIDM01051	Ovarian Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation altering degron motif	0.5641
p.P1573S	ACH-000936	Ovarian Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation altering degron motif	0.5641
p.P1573S	EFO-27	ovary	COSMIC	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation altering degron motif	0.5641
p.V408M	SIDM00438	B-Lymphoblastic Leukemia	GDSC	DNLDAYSHIP	CBL_PTK	409:418	Mutation rewiring degron network	0.3056
p.V408M	MN-60	haematopoietic and lymphoid tissue	COSMIC	DNLDAYSHIP	CBL_PTK	409:418	Mutation rewiring degron network	0.3056
p.P1545L	SIDM00628	Breast Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	1535:1542	Mutation rewiring degron network	0.25
p.Q888R	ACH-000994	Endometrial/Uterine Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1944
p.P1088L	ACH-000994	Endometrial/Uterine Cancer	CCLE	STPSPHLVPSP	DEG_COP1_1	1078:1088	Mutation altering degron motif	0.6471
p.P1585L	ACH-001201	Brain Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	1572:1576	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPN23

UniProt ID: Q9H3S7

Entrez ID: 25930

Protein name: Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPN23 in