DegronMD

Uniprot ID: Q9H3S7

Source protein: Tyrosine-protein phosphatase non-receptor type 23

Source gene: PTPN23

Class: DEG_COP1_1

Location: 1560:1567

E3 ligase: COP1

DEGRON score: 0.9739

ASA_SCORE: 102.625

COIL: 0.9679

CONS_SCORE: 0.2611

DSS_SCORE: 0.8506

HELIX: 0.0149

FCONS_SCORE: 0.9461

RIG_SCORE: 0.5172

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1577M	TCGA-CV-6953	HNSC	TCGA	EEPPVPEA	DEG_COP1_1	0.0556
p.L1577M	DO14278	HNSC	ICGC	EEPPVPEA	DEG_COP1_1	0.0556
p.A1567V	TCGA-D1-A15X	UCEC	TCGA	EEPPVPEA	DEG_COP1_1	0.5825
p.A1567V	DO43274	UCEC	ICGC	EEPPVPEA	DEG_COP1_1	0.5825
p.L1552P	DO50741	LICA	ICGC	EEPPVPEA	DEG_COP1_1	0.1111
p.S1569R	DO228355	MALY	ICGC	EEPPVPEA	DEG_COP1_1	0.2778
p.P1558L	DO222557	MELA	ICGC	EEPPVPEA	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	DEG_COP1_1	1560:1567	EEPPVPEA	COP1	0.9739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons