DegronMD

Uniprot ID: Q9H3S7

Source protein: Tyrosine-protein phosphatase non-receptor type 23

Source gene: PTPN23

Class: DEG_SCF_FBW7_1

Location: 1535:1542

E3 ligase: FBXW7

DEGRON score: 0.9893

ASA_SCORE: 96.0375

COIL: 0.9564

CONS_SCORE: 0.2755

DSS_SCORE: 0.7516

HELIX: 0.0143

FCONS_SCORE: 1.0715

RIG_SCORE: 0.4897

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1530Q	TCGA-55-6981	LUAD	TCGA	PESTPIPS	DEG_SCF_FBW7_1	0.1944
p.P1530Q	DO24265	LUAD	ICGC	PESTPIPS	DEG_SCF_FBW7_1	0.1944
p.P1546T	TCGA-AA-3492	COAD	TCGA	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1546T	TCGA-AA-A01R	COAD	TCGA	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1546T	TCGA-BG-A3EW	UCEC	TCGA	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1546T	TCGA-EI-6882	READ	TCGA	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1546T	DO7934	COAD	ICGC	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1546T	DO8224	COAD	ICGC	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1546T	DO36531	READ	ICGC	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1546T	DO48172	UCEC	ICGC	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1546T	SIDM00945	Colorectal Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1546T	SIDM00282	Colorectal Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.L1548I	TCGA-OR-A5JA	ACC	TCGA	PESTPIPS	DEG_SCF_FBW7_1	0.1667
p.L1552P	DO50741	LICA	ICGC	PESTPIPS	DEG_SCF_FBW7_1	0.0556
p.S1542F	DO42304	UCEC	ICGC	PESTPIPS	DEG_SCF_FBW7_1	0.9093
p.P1531S	SIDM00373	Endometrial Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1531S	ACH-000974	Endometrial/Uterine Cancer	CCLE	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1531S	ACH-002026	Endometrial/Uterine Cancer	CCLE	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1531S	SNG-M	endometrium	COSMIC	PESTPIPS	DEG_SCF_FBW7_1	0.2222
p.P1547T	SIDM00630	Breast Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	0.1944
p.P1547T	ACH-000876	Breast Cancer	CCLE	PESTPIPS	DEG_SCF_FBW7_1	0.1944
p.P1547T	MDA-MB-415	breast	COSMIC	PESTPIPS	DEG_SCF_FBW7_1	0.1944
p.P1526T	SIDM00928	Breast Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	0.0833
p.P1526T	CAL-85-1	breast	COSMIC	PESTPIPS	DEG_SCF_FBW7_1	0.0833
p.P1530S	SIDM00772	Breast Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	0.1944
p.P1530S	ACH-000755	Breast Cancer	CCLE	PESTPIPS	DEG_SCF_FBW7_1	0.1944
p.P1530S	HCC2218	breast	COSMIC	PESTPIPS	DEG_SCF_FBW7_1	0.1944
p.G1528D	SIDM00251	Gastric Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	0.1389
p.G1528D	ACH-000949	Gastric Cancer	CCLE	PESTPIPS	DEG_SCF_FBW7_1	0.1389
p.G1528D	TGBC11TKB	stomach	COSMIC	PESTPIPS	DEG_SCF_FBW7_1	0.1389
p.P1547R	SIDM00858	Osteosarcoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	0.1944
p.P1547R	G-292_Clone_A141B1	bone	COSMIC	PESTPIPS	DEG_SCF_FBW7_1	0.1944
p.P1545L	SIDM00628	Breast Carcinoma	GDSC	PESTPIPS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PESTPIPS

Degron related mutations and impact score

Drug responses associated with PTPN23 mutations

All proteins holding degron of PESTPIPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	DEG_SCF_FBW7_1	1535:1542	PESTPIPS	FBXW7	0.9893	More...