DegronMD

Uniprot ID: Q9H3S7

Source protein: Tyrosine-protein phosphatase non-receptor type 23

Source gene: PTPN23

Class: DEG_SCF_FBW7_1

Location: 540:546

E3 ligase: FBXW7

DEGRON score: 0.8823

ASA_SCORE: 60.7857

COIL: 0.9491

CONS_SCORE: 0.3101

DSS_SCORE: 0.3975

HELIX: 0.0427

FCONS_SCORE: 0.8555

RIG_SCORE: 0.7054

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A539P	TCGA-2G-AAG9	TGCT	TCGA	LPTPALS	DEG_SCF_FBW7_1	0.3056
p.R537W	TCGA-AN-A0AK	BRCA	TCGA	LPTPALS	DEG_SCF_FBW7_1	0.25
p.A544T	TCGA-AX-A2HC	UCEC	TCGA	LPTPALS	DEG_SCF_FBW7_1	0.6028
p.A539T	TCGA-BR-7851	STAD	TCGA	LPTPALS	DEG_SCF_FBW7_1	0.3056
p.R537L	TCGA-GN-A262	SKCM	TCGA	LPTPALS	DEG_SCF_FBW7_1	0.25
p.Q554P	TCGA-VQ-AA6F	STAD	TCGA	LPTPALS	DEG_SCF_FBW7_1	0.1111
p.E537K	DO2401	BRCA	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.25
p.A538P	DO5752	BRCA	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.2778
p.K544T	DO50931	LICA	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.7306
p.R550K	DO227538	ORCA	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.6667
p.P543L	SIDM00654	Small Cell Lung Carcinoma	GDSC	LPTPALS	DEG_SCF_FBW7_1	0.7582
p.P543L	SIDM00793	Burkitt's Lymphoma	GDSC	LPTPALS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00203	AP-3 complex subunit beta-1	DEG_SCF_FBW7_1	833:839	LPTPALS	FBXW7	0.9569	More...
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	DEG_SCF_FBW7_1	540:546	LPTPALS	FBXW7	0.8823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons