DegronMD

Uniprot ID: O00203

Source protein: AP-3 complex subunit beta-1

Source gene: AP3B1

Class: DEG_SCF_FBW7_1

Location: 833:839

E3 ligase: FBXW7

DEGRON score: 0.9569

ASA_SCORE: 74.5

COIL: 0.9104

CONS_SCORE: 0.2086

DSS_SCORE: 0.3559

HELIX: 0.0303

FCONS_SCORE: 0.9106

RIG_SCORE: 0.7518

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G848D	TCGA-2W-A8YY	CESC	TCGA	LPTPALS	DEG_SCF_FBW7_1	0.0833
p.G848D	DO223732	CESC	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.0833
p.L842F	TCGA-95-7944	LUAD	TCGA	LPTPALS	DEG_SCF_FBW7_1	0.25
p.L842F	DO25163	LUAD	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.25
p.V827L	TCGA-BH-A0DQ	BRCA	TCGA	LPTPALS	DEG_SCF_FBW7_1	0.1667
p.V827L	DO1502	BRCA	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.1667
p.L846I	TCGA-CR-7370	HNSC	TCGA	LPTPALS	DEG_SCF_FBW7_1	0.1389
p.L846I	DO14426	HNSC	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.1389
p.A837D	TCGA-DX-A6YV	SARC	TCGA	LPTPALS	DEG_SCF_FBW7_1	0.6682
p.A837D	DO220011	SARC	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.6682
p.D823V	DO225233	BRCA	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.0556
p.M843V	DO231983	LICA	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.2222
p.T835K	DO229041	LICA	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.7306
p.T835K	DO229008	LICA	ICGC	LPTPALS	DEG_SCF_FBW7_1	0.7306
p.P840S	SIDM00217	Colorectal Carcinoma	GDSC	LPTPALS	DEG_SCF_FBW7_1	0.3056
p.P840S	SNU-1040	large_intestine	COSMIC	LPTPALS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00203	AP-3 complex subunit beta-1	DEG_SCF_FBW7_1	833:839	LPTPALS	FBXW7	0.9569	More...
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	DEG_SCF_FBW7_1	540:546	LPTPALS	FBXW7	0.8823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons