DegronMD

Uniprot ID: Q9H3S7

Source protein: Tyrosine-protein phosphatase non-receptor type 23

Source gene: PTPN23

Class: CBL_PTK

Location: 409:418

E3 ligase: CBL

DEGRON score: 0.7467

ASA_SCORE: 73.55

COIL: 0.6846

CONS_SCORE: 0.2898

DSS_SCORE: 0.4122

HELIX: 0.2998

FCONS_SCORE: 0.6543

RIG_SCORE: 0.7609

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A426T	TCGA-AX-A0J1	UCEC	TCGA	DNLDAYSHIP	CBL_PTK	0.1111
p.S400A	TCGA-B5-A1MR	UCEC	TCGA	DNLDAYSHIP	CBL_PTK	0.0833
p.A413T	TCGA-EE-A2MQ	SKCM	TCGA	DNLDAYSHIP	CBL_PTK	0.6028
p.A413T	DO38711	STAD	ICGC	DNLDAYSHIP	CBL_PTK	0.6028
p.R411W	DO1608	BRCA	ICGC	DNLDAYSHIP	CBL_PTK	0.8634
p.R401C	DO223732	CESC	ICGC	DNLDAYSHIP	CBL_PTK	0.1111
p.R401C	DO41903	UCEC	ICGC	DNLDAYSHIP	CBL_PTK	0.1111
p.R401H	DO8490	COAD	ICGC	DNLDAYSHIP	CBL_PTK	0.1111
p.P417L	DO233270	GACA	ICGC	DNLDAYSHIP	CBL_PTK	0.7582
p.K424N	DO229018	LICA	ICGC	DNLDAYSHIP	CBL_PTK	0.2778
p.R411L	DO37515	SKCM	ICGC	DNLDAYSHIP	CBL_PTK	0.8428
p.Q428P	DO222393	STAD	ICGC	DNLDAYSHIP	CBL_PTK	0.0556
p.A418T	DO229242	THCA	ICGC	DNLDAYSHIP	CBL_PTK	0.7139
p.A418T	DO41572	UCEC	ICGC	DNLDAYSHIP	CBL_PTK	0.7139
p.L421R	SIDM01090	Colorectal Carcinoma	GDSC	DNLDAYSHIP	CBL_PTK	0.25
p.L421R	ACH-000943	Colon/Colorectal Cancer	CCLE	DNLDAYSHIP	CBL_PTK	0.25
p.L421R	RKO	large_intestine	COSMIC	DNLDAYSHIP	CBL_PTK	0.25
p.V408M	SIDM00438	B-Lymphoblastic Leukemia	GDSC	DNLDAYSHIP	CBL_PTK	0.3056
p.V408M	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	DNLDAYSHIP	CBL_PTK	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	CBL_PTK	409:418	DNLDAYSHIP	CBL	0.7467	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons