DegronMD

Uniprot ID: Q9H3S7

Source protein: Tyrosine-protein phosphatase non-receptor type 23

Source gene: PTPN23

Class: DEG_COP1_1

Location: 1078:1088

E3 ligase: COP1

DEGRON score: 0.567

ASA_SCORE: 90.3818

COIL: 0.9585

CONS_SCORE: 0.2812

DSS_SCORE: 0.7955

HELIX: 0.0123

FCONS_SCORE: 0.9553

RIG_SCORE: 0.4858

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1070Q	TCGA-21-1071	LUSC	TCGA	STPSPHLVPSP	DEG_COP1_1	0.1111
p.R1070Q	DO228879	LICA	ICGC	STPSPHLVPSP	DEG_COP1_1	0.1111
p.P1096L	SIDM01943	Colorectal Carcinoma	GDSC	STPSPHLVPSP	DEG_COP1_1	0.1111
p.P1088L	ACH-000994	Endometrial/Uterine Cancer	CCLE	STPSPHLVPSP	DEG_COP1_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	DEG_COP1_1	1078:1088	STPSPHLVPSP	COP1	0.567	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons