DegronMD - P51587(BRCA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1771C	TCGA-05-4382	LUAD	TCGA	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.1389
p.G1771C	DO24900	LUAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.1389
p.H1752N	TCGA-26-6174	GBM	TCGA	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.1389
p.H1752N	DO11076	GBM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.1389
p.L3346F	TCGA-4J-AA1J	CESC	TCGA	SGSTGE	DEG_Kelch_Keap1_1	3354:3359	Mutation rewiring degron network	0.1111
p.L3346F	DO219718	CESC	ICGC	SGSTGE	DEG_Kelch_Keap1_1	3354:3359	Mutation rewiring degron network	0.1111
p.Q649H	TCGA-4Z-AA7W	BLCA	TCGA	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation rewiring degron network	0.1111
p.Q649H	DO218984	BLCA	ICGC	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation rewiring degron network	0.1111
p.C554F	TCGA-73-4662	LUAD	TCGA	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.C554F	DO229022	LICA	ICGC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.C554F	DO24790	LUAD	ICGC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.S396C	TCGA-77-6843	LUSC	TCGA	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation rewiring degron network	0.1944
p.S396C	DO27588	LUSC	ICGC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation rewiring degron network	0.1944
p.V2503F	TCGA-91-6848	LUAD	TCGA	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.0556
p.V2503F	DO23846	LUAD	ICGC	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.0556
p.V2503L	TCGA-92-8064	LUSC	TCGA	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.0556
p.V2503L	DO26957	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.0556
p.A577S	TCGA-97-7554	LUAD	TCGA	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0833
p.A577S	DO23592	LUAD	ICGC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0833
p.K575N	TCGA-A5-A2K5	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	564:568	Mutation substituting flanking lysine	0.25
p.K575N	DO41379	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation substituting flanking lysine	0.25
p.E386A	TCGA-AJ-A3EK	UCEC	TCGA	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation altering degron motif	0.659
p.E386A	DO41584	UCEC	ICGC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation altering degron motif	0.659
p.I1772S	TCGA-AP-A059	UCEC	TCGA	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.1111
p.I1772S	DO41361	UCEC	ICGC	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.1111
p.Q569H	TCGA-AP-A0LM	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.3056
p.Q569H	DO43306	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.3056
p.S571F	TCGA-AP-A0LM	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.S571F	DO43306	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.G1761V	TCGA-AP-A0LM	UCEC	TCGA	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation altering degron motif	0.7532
p.G1761V	DO43306	UCEC	ICGC	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation altering degron motif	0.7532
p.L557V	TCGA-AX-A05Z	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1389
p.L557V	DO40884	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1389
p.S641Y	TCGA-AZ-4315	COAD	TCGA	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation altering degron motif	0.712
p.S641Y	DO8842	COAD	ICGC	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation altering degron motif	0.712
p.R2520Q	TCGA-AZ-4315	COAD	TCGA	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.25
p.R2520Q	DO8842	COAD	ICGC	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.25
p.R2520L	TCGA-C5-A7UC	CESC	TCGA	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.25
p.R2520L	DO49889	CESC	ICGC	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.25
p.R645I	TCGA-CA-6717	COAD	TCGA	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation rewiring degron network	0.2222
p.R645I	DO8264	COAD	ICGC	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation rewiring degron network	0.2222
p.N1758H	TCGA-CA-6717	COAD	TCGA	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.3056
p.N1758H	DO8264	COAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.3056
p.Q2506R	TCGA-D1-A1NZ	UCEC	TCGA	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.1389
p.Q2506R	DO41536	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.1389
p.P375S	TCGA-DA-A95Z	SKCM	TCGA	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation rewiring degron network	0.1944
p.P375S	DO219481	SKCM	ICGC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation rewiring degron network	0.1944
p.P375S	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation rewiring degron network	0.1944
p.P375S	ACH-000894	Lung Cancer	CCLE	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation rewiring degron network	0.1944
p.S384F	TCGA-DD-A4NL	LIHC	TCGA	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation altering degron motif	0.9093
p.S384F	DO44934	LIHC	ICGC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation altering degron motif	0.9093
p.N633K	TCGA-DX-A3LU	SARC	TCGA	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation rewiring degron network	0.2778
p.N633K	DO219967	SARC	ICGC	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation rewiring degron network	0.2778
p.P555L	TCGA-EE-A29C	SKCM	TCGA	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0833
p.P555L	DO222727	MELA	ICGC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0833
p.P555L	DO38028	SKCM	ICGC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0833
p.E626K	TCGA-EE-A2MK	SKCM	TCGA	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation rewiring degron network	0.0833
p.E626K	DO38177	SKCM	ICGC	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation rewiring degron network	0.0833
p.P2519H	TCGA-EY-A1GF	UCEC	TCGA	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.2778
p.P2519H	DO41704	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.2778
p.H1752Y	TCGA-FW-A3R5	SKCM	TCGA	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.1389
p.H1752Y	DO37406	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.1389
p.D381G	TCGA-K4-A6FZ	BLCA	TCGA	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation altering degron motif	0.7198
p.D381G	DO44045	BLCA	ICGC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation altering degron motif	0.7198
p.Y1749H	TCGA-MP-A4T8	LUAD	TCGA	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.0556
p.Y1749H	DO45348	LUAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.0556
p.N556S	TCGA-P4-AAVM	KIRP	TCGA	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1111
p.N556S	DO219695	KIRP	ICGC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1111
p.S562N	DO230342	COCA	ICGC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.2778
p.S562N	ACH-000578	Lung Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.2778
p.N372H	DO229005	COCA	ICGC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation rewiring degron network	0.1111
p.N372H	DO234285	ESAD	ICGC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation rewiring degron network	0.1111
p.N372H	DO229505	LAML	ICGC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation rewiring degron network	0.1111
p.N372H	DO230548	LUSC	ICGC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation rewiring degron network	0.1111
p.N372H	DO231056	LUSC	ICGC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation rewiring degron network	0.1111
p.S401L	DO222469	ESCA	ICGC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation rewiring degron network	0.0556
p.E386D	DO229183	NKTL	ICGC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation altering degron motif	0.5647
p.T939S	DO229253	THCA	ICGC	MVLYGD	LIG_APCC_ABBA_1	927:932	Mutation rewiring degron network	0.1389
p.K382Q	SIDM01483	Melanoma	GDSC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation altering degron motif	0.5833
p.K382Q	ACH-000582	Skin Cancer	CCLE	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation altering degron motif	0.5833
p.K382Q	COLO-741	large intestine	COSMIC	SDKISKEVVPSL	DEG_COP1_1	380:391	Mutation altering degron motif	0.5833
p.A938E	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	MVLYGD	LIG_APCC_ABBA_1	927:932	Mutation rewiring degron network	0.1667
p.A938E	ACH-000766	Lung Cancer	CCLE	MVLYGD	LIG_APCC_ABBA_1	927:932	Mutation rewiring degron network	0.1667
p.A938E	NCI-H1648	lung	COSMIC	MVLYGD	LIG_APCC_ABBA_1	927:932	Mutation rewiring degron network	0.1667
p.D935N	SIDM00057	Neuroblastoma	GDSC	MVLYGD	LIG_APCC_ABBA_1	927:932	Mutation rewiring degron network	0.25
p.T2515I	SIDM00227	Neuroblastoma	GDSC	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation altering degron motif	0.7078
p.L929S	SIDM00529	Breast Carcinoma	GDSC	MVLYGD	LIG_APCC_ABBA_1	927:932	Mutation altering degron motif	0.7667
p.L929S	SIDM00875	Breast Carcinoma	GDSC	MVLYGD	LIG_APCC_ABBA_1	927:932	Mutation altering degron motif	0.7667
p.L929S	SIDM00793	Burkitt's Lymphoma	GDSC	MVLYGD	LIG_APCC_ABBA_1	927:932	Mutation altering degron motif	0.7667
p.P2505L	SIDM00092	Ovarian Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.1111
p.P2505L	ACH-000617	Ovarian Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.1111
p.P2505L	OVCAR-4	ovary	COSMIC	AKTST	DEG_SPOP_SBC_1	2513:2517	Mutation rewiring degron network	0.1111
p.T3357R	SIDM00893	Breast Carcinoma	GDSC	SGSTGE	DEG_Kelch_Keap1_1	3354:3359	Mutation altering degron motif	0.7876
p.T3357R	BT-20	breast	COSMIC	SGSTGE	DEG_Kelch_Keap1_1	3354:3359	Mutation altering degron motif	0.7876
p.G578D	SIDM00140	Melanoma	GDSC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.G578D	ACH-000968	Skin Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.G578D	COLO-792	skin	COSMIC	PATTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.K644R	SIDM00675	Breast Carcinoma	GDSC	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation substituting flanking lysine	0.3611
p.K644R	ACH-000276	Breast Cancer	CCLE	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation substituting flanking lysine	0.3611
p.K644R	HCC38	breast	COSMIC	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation substituting flanking lysine	0.3611
p.D651Y	SIDM01588	Endometrial Carcinoma	GDSC	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation rewiring degron network	0.0556
p.D651Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGLLHS	DEG_SCF_TRCP1_1	635:641	Mutation rewiring degron network	0.0556
p.S1750F	ACH-001634	Leukemia	CCLE	DSGYLS	DEG_SCF_TRCP1_1	1759:1764	Mutation rewiring degron network	0.0833
p.E919K	ACH-001991	Primary	CCLE	MVLYGD	LIG_APCC_ABBA_1	927:932	Mutation rewiring degron network	0.1111

Kaplan plot for BRCA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRCA2

UniProt ID: P51587

Entrez ID: 675

Protein name: Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRCA2 in