DegronMD

Uniprot ID: P51587

Source protein: Breast cancer type 2 susceptibility protein

Source gene: BRCA2

Class: DEG_SCF_TRCP1_1

Location: 1759:1764

E3 ligase: BTRC

DEGRON score: 0.9215

ASA_SCORE: 74.9833

COIL: 0.6735

CONS_SCORE: 0.3035

DSS_SCORE: 0.407

HELIX: 0.24

FCONS_SCORE: 1.0369

RIG_SCORE: 0.725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1771C	TCGA-05-4382	LUAD	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.1389
p.G1771C	DO24900	LUAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.1389
p.H1752N	TCGA-26-6174	GBM	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.1389
p.H1752N	DO11076	GBM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.1389
p.I1772S	TCGA-AP-A059	UCEC	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.1111
p.I1772S	DO41361	UCEC	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.1111
p.G1761V	TCGA-AP-A0LM	UCEC	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.7532
p.G1761V	DO43306	UCEC	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.7532
p.N1758H	TCGA-CA-6717	COAD	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.3056
p.N1758H	DO8264	COAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.3056
p.H1752Y	TCGA-FW-A3R5	SKCM	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.1389
p.H1752Y	DO37406	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.1389
p.Y1749H	TCGA-MP-A4T8	LUAD	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.0556
p.Y1749H	DO45348	LUAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.0556
p.S1750F	ACH-001634	Leukemia	CCLE	DSGYLS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51587	Breast cancer type 2 susceptibility protein	DEG_SCF_TRCP1_1	1759:1764	DSGYLS	BTRC	0.9215	More...
Q8WX93	Palladin	DEG_SCF_TRCP1_1	201:206	DSGYLS	BTRC	0.9801	More...
Q5JPB2	Zinc finger protein 831	DEG_SCF_TRCP1_1	343:348	DSGYLS	BTRC	0.7417	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons