DegronMD

Uniprot ID: Q5JPB2

Source protein: Zinc finger protein 831

Source gene: ZNF831

Class: DEG_SCF_TRCP1_1

Location: 343:348

E3 ligase: BTRC

DEGRON score: 0.7417

ASA_SCORE: 87.0833

COIL: 0.7857

CONS_SCORE: 0.7763

DSS_SCORE: 0.5628

HELIX: 0.0392

FCONS_SCORE: 1.1556

RIG_SCORE: 0.6247

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q355E	TCGA-17-Z031	LUAD	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.1389
p.R335W	TCGA-28-2513	GBM	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.1111
p.R335W	TCGA-EE-A29D	SKCM	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.1111
p.R335W	DO12766	GBM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.1111
p.R335W	DO38123	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.1111
p.R335Q	TCGA-2H-A9GR	ESCA	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.1111
p.Q355K	TCGA-49-AARQ	LUAD	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.1389
p.Q355K	DO51189	LUAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.1389
p.R337W	TCGA-AX-A2HD	UCEC	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.1667
p.R337W	DO42608	UCEC	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.1667
p.S344L	TCGA-CG-4460	STAD	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.7667
p.S344L	DO38427	STAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.7667
p.P356L	TCGA-CR-7380	HNSC	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.1111
p.P356L	DO14734	HNSC	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.1111
p.S348L	DO49472	PACA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.7667
p.L347M	DO232224	PBCA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.5999
p.E333V	DO229470	SKCA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.0556
p.A353T	SIDM02048	Colorectal Carcinoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.A353T	SIDM01612	Endometrial Carcinoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.A353T	ACH-000946	Endometrial/Uterine Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.A353V	SIDM00722	Mesothelioma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.A353V	SIDM00631	Breast Carcinoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.A353V	SIDM00874	Breast Carcinoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.A353V	SIDM00103	Mesothelioma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.A353V	SIDM00511	Small Cell Lung Carcinoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.A353V	SIDM00462	Acute Myeloid Leukemia	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.A353V	SIDM00873	Non-Cancerous	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.S350F	SIDM00332	Breast Carcinoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.2778
p.S350F	ACH-001819	Breast Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	0.2778
p.S350F	MFM-223	breast	COSMIC	DSGYLS	DEG_SCF_TRCP1_1	0.2778
p.R349H	SIDM01146	Gastric Carcinoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.3056
p.R349H	ACH-000932	Gastric Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	0.3056
p.C339S	SIDM01591	Breast Carcinoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.2222
p.C339S	ACH-000540	Non-Cancerous	CCLE	DSGYLS	DEG_SCF_TRCP1_1	0.2222
p.H357Y	ACH-001414	Bladder Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	0.0833
p.E354D	ACH-002120	Skin Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51587	Breast cancer type 2 susceptibility protein	DEG_SCF_TRCP1_1	1759:1764	DSGYLS	BTRC	0.9215	More...
Q8WX93	Palladin	DEG_SCF_TRCP1_1	201:206	DSGYLS	BTRC	0.9801	More...
Q5JPB2	Zinc finger protein 831	DEG_SCF_TRCP1_1	343:348	DSGYLS	BTRC	0.7417	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGYLS

Degron related mutations and impact score

Drug responses associated with ZNF831 mutations

All proteins holding degron of DSGYLS