DegronMD - Q8WX93(PALLD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S755Y	TCGA-55-6981	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	756:760	Mutation blocking phosphorylation signal	0.75
p.P207S	TCGA-D3-A8GM	SKCM	TCGA	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.3056
p.S202R	TCGA-D3-A8GQ	SKCM	TCGA	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation altering degron motif	0.7427
p.E751Q	TCGA-XF-A8HD	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	756:760	Mutation blocking phosphorylation signal	0.6389
p.P213L	DO218990	BLCA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.1389
p.L762V	DO49964	CESC	ICGC	PSSSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.2778
p.E199Q	DO234243	ESAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.2778
p.H204Y	DO50999	LAML	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation altering degron motif	0.7229
p.Q212H	DO228941	LICA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.1667
p.C198F	DO229045	LICA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.25
p.I207N	DO24399	LUAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.3056
p.H754Y	DO24656	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	756:760	Mutation blocking phosphorylation signal	0.7222
p.E210K	DO220878	MELA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.2222
p.G200E	DO222683	MELA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.3056
p.G200E	DO37417	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.3056
p.H197Y	DO222775	MELA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.2222
p.H197Y	DO47665	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.2222
p.L769R	DO219397	PRAD	ICGC	PSSSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.0833
p.R199Q	DO37567	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.2778
p.R199Q	DO51301	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.2778
p.R199Q	DO42713	UCEC	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.2778
p.D196N	DO37406	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.1944
p.D202N	DO37406	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation altering degron motif	0.6932
p.A192V	DO222392	STAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation blocking phosphorylation signal	0.5278
p.L203I	DO40804	UCEC	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation altering degron motif	0.7174
p.R202H	DO41542	UCEC	ICGC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation altering degron motif	0.8244
p.E770K	SIDM00781	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	756:760	Mutation rewiring degron network	0.0556
p.P193L	SIDM01106	Melanoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.1111
p.P193L	ACH-000822	Skin Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.1111
p.P193L	SK-MEL-24	skin	COSMIC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.1111
p.S199P	SIDM01077	Prostate Carcinoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.2778
p.S199P	ACH-000115	Prostate Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.2778
p.S199P	VCaP	prostate	COSMIC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.2778
p.E196Q	SIDM01635	Glioblastoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.1944
p.E196Q	ACH-000027	Brain Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.1944
p.E196Q	ACH-000036	Brain Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation rewiring degron network	0.1944
p.Q203R	NCI-H250	lung	COSMIC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation altering degron motif	0.7329
p.Y766F	SNU-C5	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	756:760	Mutation blocking phosphorylation signal	0.6111
p.E205Q	WM1552C	skin	COSMIC	DSGYLS	DEG_SCF_TRCP1_1	201:206	Mutation altering degron motif	0.6744

Kaplan plot for PALLD in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PALLD

UniProt ID: Q8WX93

Entrez ID: 23022

Protein name: Palladin (SIH002) (Sarcoma antigen NY-SAR-77)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PALLD in