DegronMD

Uniprot ID: Q8WX93

Source protein: Palladin

Source gene: PALLD

Class: DEG_SCF_TRCP1_1

Location: 201:206

E3 ligase: BTRC

DEGRON score: 0.9801

ASA_SCORE: 59.6667

COIL: 0.498

CONS_SCORE: 0.5696

DSS_SCORE: 0.7347

HELIX: 0.0473

FCONS_SCORE: 1.6336

RIG_SCORE: 0.5621

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P207S	TCGA-D3-A8GM	SKCM	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.3056
p.S202R	TCGA-D3-A8GQ	SKCM	TCGA	DSGYLS	DEG_SCF_TRCP1_1	0.7427
p.P213L	DO218990	BLCA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.1389
p.E199Q	DO234243	ESAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.2778
p.H204Y	DO50999	LAML	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.7229
p.Q212H	DO228941	LICA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.1667
p.C198F	DO229045	LICA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.25
p.I207N	DO24399	LUAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.3056
p.E210K	DO220878	MELA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.2222
p.G200E	DO222683	MELA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.3056
p.G200E	DO37417	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.3056
p.H197Y	DO222775	MELA	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.2222
p.H197Y	DO47665	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.2222
p.R199Q	DO37567	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.2778
p.R199Q	DO51301	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.2778
p.R199Q	DO42713	UCEC	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.2778
p.D196N	DO37406	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.D202N	DO37406	SKCM	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.6932
p.A192V	DO222392	STAD	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.5278
p.L203I	DO40804	UCEC	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.7174
p.R202H	DO41542	UCEC	ICGC	DSGYLS	DEG_SCF_TRCP1_1	0.8244
p.P193L	SIDM01106	Melanoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.1111
p.P193L	ACH-000822	Skin Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	0.1111
p.P193L	SK-MEL-24	skin	COSMIC	DSGYLS	DEG_SCF_TRCP1_1	0.1111
p.S199P	SIDM01077	Prostate Carcinoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.2778
p.S199P	ACH-000115	Prostate Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	0.2778
p.S199P	VCaP	prostate	COSMIC	DSGYLS	DEG_SCF_TRCP1_1	0.2778
p.E196Q	SIDM01635	Glioblastoma	GDSC	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.E196Q	ACH-000027	Brain Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.E196Q	ACH-000036	Brain Cancer	CCLE	DSGYLS	DEG_SCF_TRCP1_1	0.1944
p.Q203R	NCI-H250	lung	COSMIC	DSGYLS	DEG_SCF_TRCP1_1	0.7329
p.E205Q	WM1552C	skin	COSMIC	DSGYLS	DEG_SCF_TRCP1_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51587	Breast cancer type 2 susceptibility protein	DEG_SCF_TRCP1_1	1759:1764	DSGYLS	BTRC	0.9215	More...
Q8WX93	Palladin	DEG_SCF_TRCP1_1	201:206	DSGYLS	BTRC	0.9801	More...
Q5JPB2	Zinc finger protein 831	DEG_SCF_TRCP1_1	343:348	DSGYLS	BTRC	0.7417	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGYLS

Degron related mutations and impact score

Drug responses associated with PALLD mutations

All proteins holding degron of DSGYLS