DegronMD

Uniprot ID: P51587

Source protein: Breast cancer type 2 susceptibility protein

Source gene: BRCA2

Class: DEG_SCF_TRCP1_1

Location: 635:641

E3 ligase: BTRC

DEGRON score: 0.8429

ASA_SCORE: 80.5

COIL: 0.7587

CONS_SCORE: 0.3049

DSS_SCORE: 0.2694

HELIX: 0.103

FCONS_SCORE: 0.9442

RIG_SCORE: 0.7046

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q649H	TCGA-4Z-AA7W	BLCA	TCGA	DSGLLHS	DEG_SCF_TRCP1_1	0.1111
p.Q649H	DO218984	BLCA	ICGC	DSGLLHS	DEG_SCF_TRCP1_1	0.1111
p.S641Y	TCGA-AZ-4315	COAD	TCGA	DSGLLHS	DEG_SCF_TRCP1_1	0.712
p.S641Y	DO8842	COAD	ICGC	DSGLLHS	DEG_SCF_TRCP1_1	0.712
p.R645I	TCGA-CA-6717	COAD	TCGA	DSGLLHS	DEG_SCF_TRCP1_1	0.2222
p.R645I	DO8264	COAD	ICGC	DSGLLHS	DEG_SCF_TRCP1_1	0.2222
p.N633K	TCGA-DX-A3LU	SARC	TCGA	DSGLLHS	DEG_SCF_TRCP1_1	0.2778
p.N633K	DO219967	SARC	ICGC	DSGLLHS	DEG_SCF_TRCP1_1	0.2778
p.E626K	TCGA-EE-A2MK	SKCM	TCGA	DSGLLHS	DEG_SCF_TRCP1_1	0.0833
p.E626K	DO38177	SKCM	ICGC	DSGLLHS	DEG_SCF_TRCP1_1	0.0833
p.K644R	SIDM00675	Breast Carcinoma	GDSC	DSGLLHS	DEG_SCF_TRCP1_1	0.3611
p.K644R	ACH-000276	Breast Cancer	CCLE	DSGLLHS	DEG_SCF_TRCP1_1	0.3611
p.K644R	HCC38	breast	COSMIC	DSGLLHS	DEG_SCF_TRCP1_1	0.3611
p.D651Y	SIDM01588	Endometrial Carcinoma	GDSC	DSGLLHS	DEG_SCF_TRCP1_1	0.0556
p.D651Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGLLHS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51587	Breast cancer type 2 susceptibility protein	DEG_SCF_TRCP1_1	635:641	DSGLLHS	BTRC	0.8429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons