DegronMD

Uniprot ID: P51587

Source protein: Breast cancer type 2 susceptibility protein

Source gene: BRCA2

Class: LIG_APCC_ABBA_1

Location: 927:932

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7458

ASA_SCORE: 77.5833

COIL: 0.5582

CONS_SCORE: 0.2905

DSS_SCORE: 0.3136

HELIX: 0.0732

FCONS_SCORE: 0.8645

RIG_SCORE: 0.8275

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T939S	DO229253	THCA	ICGC	MVLYGD	LIG_APCC_ABBA_1	0.1389
p.A938E	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	MVLYGD	LIG_APCC_ABBA_1	0.1667
p.A938E	ACH-000766	Lung Cancer	CCLE	MVLYGD	LIG_APCC_ABBA_1	0.1667
p.A938E	NCI-H1648	lung	COSMIC	MVLYGD	LIG_APCC_ABBA_1	0.1667
p.D935N	SIDM00057	Neuroblastoma	GDSC	MVLYGD	LIG_APCC_ABBA_1	0.25
p.L929S	SIDM00529	Breast Carcinoma	GDSC	MVLYGD	LIG_APCC_ABBA_1	0.7667
p.L929S	SIDM00875	Breast Carcinoma	GDSC	MVLYGD	LIG_APCC_ABBA_1	0.7667
p.L929S	SIDM00793	Burkitt's Lymphoma	GDSC	MVLYGD	LIG_APCC_ABBA_1	0.7667
p.E919K	ACH-001991	Primary	CCLE	MVLYGD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51587	Breast cancer type 2 susceptibility protein	LIG_APCC_ABBA_1	927:932	MVLYGD	APC,CDC20,FZR1	0.7458	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons