DegronMD

Uniprot ID: P51587

Source protein: Breast cancer type 2 susceptibility protein

Source gene: BRCA2

Class: DEG_Kelch_Keap1_1

Location: 3354:3359

E3 ligase: KEAP1

DEGRON score: 0.7758

ASA_SCORE: 65.35

COIL: 0.8448

CONS_SCORE: 0.3269

DSS_SCORE: 0.3033

HELIX: 0.1237

FCONS_SCORE: 0.7992

RIG_SCORE: 0.6665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L3346F	TCGA-4J-AA1J	CESC	TCGA	SGSTGE	DEG_Kelch_Keap1_1	0.1111
p.L3346F	DO219718	CESC	ICGC	SGSTGE	DEG_Kelch_Keap1_1	0.1111
p.T3357R	SIDM00893	Breast Carcinoma	GDSC	SGSTGE	DEG_Kelch_Keap1_1	0.7876
p.T3357R	BT-20	breast	COSMIC	SGSTGE	DEG_Kelch_Keap1_1	0.7876

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_Kelch_Keap1_1	2598:2603	SGSTGE	KEAP1	0.96	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_Kelch_Keap1_1	3354:3359	SGSTGE	KEAP1	0.7758	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons