DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: DEG_Kelch_Keap1_1

Location: 2598:2603

E3 ligase: KEAP1

DEGRON score: 0.96

ASA_SCORE: 82.6167

COIL: 0.9402

CONS_SCORE: 0.3062

DSS_SCORE: 0.6519

HELIX: 0.0313

FCONS_SCORE: 0.9151

RIG_SCORE: 0.5081

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2601I	TCGA-64-1679	LUAD	TCGA	SGSTGE	DEG_Kelch_Keap1_1	0.7078
p.T2601I	DO26200	LUAD	ICGC	SGSTGE	DEG_Kelch_Keap1_1	0.7078
p.R2611C	TCGA-AA-3660	COAD	TCGA	SGSTGE	DEG_Kelch_Keap1_1	0.1111
p.R2611C	DO7795	COAD	ICGC	SGSTGE	DEG_Kelch_Keap1_1	0.1111
p.S2604G	TCGA-D1-A103	UCEC	TCGA	SGSTGE	DEG_Kelch_Keap1_1	0.3056
p.S2604G	DO42312	UCEC	ICGC	SGSTGE	DEG_Kelch_Keap1_1	0.3056
p.G2595W	TCGA-EM-A2CJ	THCA	TCGA	SGSTGE	DEG_Kelch_Keap1_1	0.25
p.G2595W	DO39360	THCA	ICGC	SGSTGE	DEG_Kelch_Keap1_1	0.25
p.S2590L	TCGA-YZ-A985	UVM	TCGA	SGSTGE	DEG_Kelch_Keap1_1	0.1111
p.P2596T	DO229018	LICA	ICGC	SGSTGE	DEG_Kelch_Keap1_1	0.2778
p.S2608T	DO220886	MELA	ICGC	SGSTGE	DEG_Kelch_Keap1_1	0.1944
p.P2613S	DO222413	MELA	ICGC	SGSTGE	DEG_Kelch_Keap1_1	0.0556
p.R2611H	SIDM02041	Colorectal Carcinoma	GDSC	SGSTGE	DEG_Kelch_Keap1_1	0.1111
p.R2611H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SGSTGE	DEG_Kelch_Keap1_1	0.1111
p.R2611H	ACH-002256	Leukemia	CCLE	SGSTGE	DEG_Kelch_Keap1_1	0.1111
p.R2611H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SGSTGE	DEG_Kelch_Keap1_1	0.1111
p.G2591C	SIDM01685	B-Lymphoblastic Leukemia	GDSC	SGSTGE	DEG_Kelch_Keap1_1	0.1389
p.G2591C	ACH-000130	Leukemia	CCLE	SGSTGE	DEG_Kelch_Keap1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_Kelch_Keap1_1	2598:2603	SGSTGE	KEAP1	0.96	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_Kelch_Keap1_1	3354:3359	SGSTGE	KEAP1	0.7758	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons