DegronMD

Uniprot ID: P51587

Source protein: Breast cancer type 2 susceptibility protein

Source gene: BRCA2

Class: DEG_COP1_1

Location: 380:391

E3 ligase: COP1

DEGRON score: 0.849

ASA_SCORE: 83.0917

COIL: 0.7533

CONS_SCORE: 0.3264

DSS_SCORE: 0.3674

HELIX: 0.1205

FCONS_SCORE: 0.9025

RIG_SCORE: 0.7476

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S396C	TCGA-77-6843	LUSC	TCGA	SDKISKEVVPSL	DEG_COP1_1	0.1944
p.S396C	DO27588	LUSC	ICGC	SDKISKEVVPSL	DEG_COP1_1	0.1944
p.E386A	TCGA-AJ-A3EK	UCEC	TCGA	SDKISKEVVPSL	DEG_COP1_1	0.659
p.E386A	DO41584	UCEC	ICGC	SDKISKEVVPSL	DEG_COP1_1	0.659
p.P375S	TCGA-DA-A95Z	SKCM	TCGA	SDKISKEVVPSL	DEG_COP1_1	0.1944
p.P375S	DO219481	SKCM	ICGC	SDKISKEVVPSL	DEG_COP1_1	0.1944
p.P375S	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	SDKISKEVVPSL	DEG_COP1_1	0.1944
p.P375S	ACH-000894	Lung Cancer	CCLE	SDKISKEVVPSL	DEG_COP1_1	0.1944
p.S384F	TCGA-DD-A4NL	LIHC	TCGA	SDKISKEVVPSL	DEG_COP1_1	0.9093
p.S384F	DO44934	LIHC	ICGC	SDKISKEVVPSL	DEG_COP1_1	0.9093
p.D381G	TCGA-K4-A6FZ	BLCA	TCGA	SDKISKEVVPSL	DEG_COP1_1	0.7198
p.D381G	DO44045	BLCA	ICGC	SDKISKEVVPSL	DEG_COP1_1	0.7198
p.N372H	DO229005	COCA	ICGC	SDKISKEVVPSL	DEG_COP1_1	0.1111
p.N372H	DO234285	ESAD	ICGC	SDKISKEVVPSL	DEG_COP1_1	0.1111
p.N372H	DO229505	LAML	ICGC	SDKISKEVVPSL	DEG_COP1_1	0.1111
p.N372H	DO230548	LUSC	ICGC	SDKISKEVVPSL	DEG_COP1_1	0.1111
p.N372H	DO231056	LUSC	ICGC	SDKISKEVVPSL	DEG_COP1_1	0.1111
p.S401L	DO222469	ESCA	ICGC	SDKISKEVVPSL	DEG_COP1_1	0.0556
p.E386D	DO229183	NKTL	ICGC	SDKISKEVVPSL	DEG_COP1_1	0.5647
p.K382Q	SIDM01483	Melanoma	GDSC	SDKISKEVVPSL	DEG_COP1_1	0.5833
p.K382Q	ACH-000582	Skin Cancer	CCLE	SDKISKEVVPSL	DEG_COP1_1	0.5833
p.K382Q	COLO-741	large_intestine	COSMIC	SDKISKEVVPSL	DEG_COP1_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51587	Breast cancer type 2 susceptibility protein	DEG_COP1_1	380:391	SDKISKEVVPSL	COP1	0.849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons