DegronMD

Uniprot ID: P51587

Source protein: Breast cancer type 2 susceptibility protein

Source gene: BRCA2

Class: DEG_SPOP_SBC_1

Location: 2513:2517

E3 ligase: SPOP

DEGRON score: 0.973

ASA_SCORE: 77.12

COIL: 0.711

CONS_SCORE: 0.4537

DSS_SCORE: 0.3126

HELIX: 0.0794

FCONS_SCORE: 0.8187

RIG_SCORE: 0.7848

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2503F	TCGA-91-6848	LUAD	TCGA	AKTST	DEG_SPOP_SBC_1	0.0556
p.V2503F	DO23846	LUAD	ICGC	AKTST	DEG_SPOP_SBC_1	0.0556
p.V2503L	TCGA-92-8064	LUSC	TCGA	AKTST	DEG_SPOP_SBC_1	0.0556
p.V2503L	DO26957	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.0556
p.R2520Q	TCGA-AZ-4315	COAD	TCGA	AKTST	DEG_SPOP_SBC_1	0.25
p.R2520Q	DO8842	COAD	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.R2520L	TCGA-C5-A7UC	CESC	TCGA	AKTST	DEG_SPOP_SBC_1	0.25
p.R2520L	DO49889	CESC	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.Q2506R	TCGA-D1-A1NZ	UCEC	TCGA	AKTST	DEG_SPOP_SBC_1	0.1389
p.Q2506R	DO41536	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	0.1389
p.P2519H	TCGA-EY-A1GF	UCEC	TCGA	AKTST	DEG_SPOP_SBC_1	0.2778
p.P2519H	DO41704	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	0.2778
p.T2515I	SIDM00227	Neuroblastoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7078
p.P2505L	SIDM00092	Ovarian Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.1111
p.P2505L	ACH-000617	Ovarian Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	0.1111
p.P2505L	OVCAR-4	ovary	COSMIC	AKTST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SPOP_SBC_1	393:397	AKTST	SPOP	0.9928	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	710:714	AKTST	SPOP	0.9259	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_SPOP_SBC_1	2513:2517	AKTST	SPOP	0.973	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1743:1747	AKTST	SPOP	0.7173	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1912:1916	AKTST	SPOP	0.8233	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	1287:1291	AKTST	SPOP	0.9661	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10802:10806	AKTST	SPOP	0.9728	More...
Q9UPW6	DNA-binding protein SATB2	DEG_SPOP_SBC_1	463:467	AKTST	SPOP	0.6389	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons