DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 10802:10806

E3 ligase: SPOP

DEGRON score: 0.9728

ASA_SCORE: 92.34

COIL: 0.7656

CONS_SCORE: 0

DSS_SCORE: 0.466

HELIX: 0.0246

FCONS_SCORE: 0

RIG_SCORE: 0.7428

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M10796I	TCGA-09-2044	OV	TCGA	AKTST	DEG_SPOP_SBC_1	0.1667
p.M10796I	DO28923	OV	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.R10809Q	TCGA-5M-AAT6	COAD	TCGA	AKTST	DEG_SPOP_SBC_1	0.25
p.R10809Q	TCGA-E6-A1LX	UCEC	TCGA	AKTST	DEG_SPOP_SBC_1	0.25
p.R10809Q	DO223703	COAD	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.R10809Q	DO229456	SKCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.R10809Q	DO41020	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.S10795T	TCGA-64-5775	LUAD	TCGA	AKTST	DEG_SPOP_SBC_1	0.1389
p.S10795T	DO26025	LUAD	ICGC	AKTST	DEG_SPOP_SBC_1	0.1389
p.A10801V	TCGA-AP-A0LM	UCEC	TCGA	AKTST	DEG_SPOP_SBC_1	0.3056
p.A10801V	TCGA-BR-8487	STAD	TCGA	AKTST	DEG_SPOP_SBC_1	0.3056
p.A10801V	TCGA-F5-6571	READ	TCGA	AKTST	DEG_SPOP_SBC_1	0.3056
p.A10801V	DO222843	MELA	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.A10801V	DO36874	READ	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.A10801V	DO47867	STAD	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.A10801V	DO43306	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.A10801V	SIDM00542	Glioblastoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.A10801V	ACH-002227	Brain Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	0.3056
p.A10801V	D-392MG	central_nervous_system	COSMIC	AKTST	DEG_SPOP_SBC_1	0.3056
p.G10816S	TCGA-CR-7399	HNSC	TCGA	AKTST	DEG_SPOP_SBC_1	0.0556
p.G10816S	DO15759	HNSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.0556
p.T10812K	TCGA-EE-A2ML	SKCM	TCGA	AKTST	DEG_SPOP_SBC_1	0.1667
p.T10812K	DO222429	MELA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.T10812K	DO37408	SKCM	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.S10814F	DO220899	MELA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1111
p.T10804A	SIDM00789	Colorectal Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.825
p.T10804A	ACH-000997	Colon/Colorectal Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	0.825
p.T10804A	ACH-001061	Colon/Colorectal Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	0.825
p.T10804A	HCT-15	large_intestine	COSMIC	AKTST	DEG_SPOP_SBC_1	0.825
p.L10792W	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.0556
p.L10792W	PC-3_[JPC-3]	lung	COSMIC	AKTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SPOP_SBC_1	393:397	AKTST	SPOP	0.9928	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	710:714	AKTST	SPOP	0.9259	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_SPOP_SBC_1	2513:2517	AKTST	SPOP	0.973	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1743:1747	AKTST	SPOP	0.7173	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1912:1916	AKTST	SPOP	0.8233	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	1287:1291	AKTST	SPOP	0.9661	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10802:10806	AKTST	SPOP	0.9728	More...
Q9UPW6	DNA-binding protein SATB2	DEG_SPOP_SBC_1	463:467	AKTST	SPOP	0.6389	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKTST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of AKTST