DegronMD - Q9UPW6(SATB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R567H	TCGA-2W-A8YY	CESC	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.R567H	TCGA-CG-5723	STAD	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.R567H	DO223732	CESC	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.R567H	DO233259	GACA	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.R567H	DO38376	STAD	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.L472I	TCGA-73-A9RS	LUAD	TCGA	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1944
p.L472I	DO51193	LUAD	ICGC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1944
p.D471Y	TCGA-85-A4JB	LUSC	TCGA	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2222
p.D471Y	DO45517	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2222
p.E557D	TCGA-A5-A0G2	UCEC	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.5647
p.E557D	DO41235	UCEC	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.5647
p.R567C	TCGA-A5-A0VP	UCEC	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.R567C	TCGA-BH-A1F8	BRCA	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.R567C	TCGA-CR-6491	HNSC	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.R567C	DO1512	BRCA	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.R567C	DO14192	HNSC	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.R567C	DO42600	UCEC	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.I555M	TCGA-AC-A23H	BRCA	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.6507
p.I555M	DO2401	BRCA	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.6507
p.R543H	TCGA-CV-5441	HNSC	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.R543H	DO15671	HNSC	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.V554A	TCGA-CV-6961	HNSC	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.5825
p.V554A	DO14566	HNSC	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.5825
p.S453N	TCGA-D5-6930	COAD	TCGA	AKTST	DEG_SPOP_SBC_1	463:467	Mutation blocking phosphorylation signal	0.5
p.S453N	DO10550	COAD	ICGC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation blocking phosphorylation signal	0.5
p.S466L	TCGA-EE-A2MC	SKCM	TCGA	AKTST	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7667
p.S466L	DO37559	SKCM	ICGC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7667
p.D553N	TCGA-FR-A726	SKCM	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.5821
p.D553N	DO48665	SKCM	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.5821
p.P548L	TCGA-GC-A3RB	BLCA	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.2222
p.P548L	DO530	BLCA	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.2222
p.R552G	TCGA-NJ-A55A	LUAD	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.7568
p.R552G	DO218945	LUAD	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.7568
p.D553Y	DO234254	ESAD	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.6214
p.E566K	DO234388	ESAD	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.1111
p.E566K	DO228176	PBCA	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.1111
p.E566K	SIDM00451	T-Lymphoblastic Leukemia	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.1111
p.E566K	ACH-000937	Leukemia	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.1111
p.E566K	PF-382	haematopoietic and lymphoid tissue	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.1111
p.D477G	DO233747	GACA	ICGC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.0556
p.K464E	DO231983	LICA	ICGC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.591
p.R552W	DO228903	LICA	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.8634
p.D477E	DO228974	LICA	ICGC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.0556
p.T469K	DO228974	LICA	ICGC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2778
p.P468T	DO229009	LICA	ICGC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.3056
p.H562N	SIDM00338	Acute Myeloid Leukemia	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.2222
p.H562N	ACH-000439	Leukemia	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.2222
p.H562N	ME-1	haematopoietic and lymphoid tissue	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.2222
p.R542C	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0556
p.R542C	ACH-002272	Lymphoma	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0556
p.R542C	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0556
p.I555V	SIDM01248	Thyroid Gland Carcinoma	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.5965
p.I555V	SIDM01167	Thyroid Gland Carcinoma	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.5965
p.I555V	ACH-000163	Thyroid Cancer	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.5965
p.I555V	ACH-001023	Thyroid Cancer	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.5965
p.I555V	CGTH-W-1	thyroid	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.5965
p.P468L	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.3056
p.P468L	ACH-000667	Lung Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.3056
p.P468L	HCC-44	lung	COSMIC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.3056
p.N546K	SIDM00445	Esophageal Carcinoma	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.1667
p.N546K	ACH-002292	Esophageal Cancer	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.1667
p.N546K	OACp4C	oesophagus	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.1667
p.N546K	NCI-H187	lung	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.1667
p.R459Q	SIDM00596	Endometrial Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2222
p.R459Q	ACH-000941	Endometrial/Uterine Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2222
p.R459Q	ACH-000954	Endometrial/Uterine Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2222
p.R459Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2222
p.R459Q	HEC-1	endometrium	COSMIC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2222
p.R543L	SIDM00927	Small Cell Lung Carcinoma	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.R543L	ACH-000871	Lung Cancer	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.R543L	NCI-H510A	lung	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.0833
p.Q462R	SIDM00500	Colorectal Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.3056
p.R463H	22RV1	prostate	COSMIC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.8244
p.V552M	NCI-H740	lung	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.7208
p.R473S	SF126	central nervous system	COSMIC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1667
p.K557N	NCI-H358	lung	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation altering degron motif	0.6918
p.S476F	WM-115	skin	COSMIC	AKTST	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.0833
p.E565V	KP-2	pancreas	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	552:558	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SATB2

UniProt ID: Q9UPW6

Entrez ID: 23314

Protein name: DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SATB2 in