DegronMD

Uniprot ID: Q9UPW6

Source protein: DNA-binding protein SATB2

Source gene: SATB2

Class: LIG_APCC_ABBAyCdc20_2

Location: 552:558

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6733

ASA_SCORE: 81.3429

COIL: 0.1079

CONS_SCORE: 0.5538

DSS_SCORE: 0.4799

HELIX: 0.8923

FCONS_SCORE: 1.1891

RIG_SCORE: 0.7464

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R567H	TCGA-2W-A8YY	CESC	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R567H	TCGA-CG-5723	STAD	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R567H	DO223732	CESC	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R567H	DO233259	GACA	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R567H	DO38376	STAD	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E557D	TCGA-A5-A0G2	UCEC	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E557D	DO41235	UCEC	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.5647
p.R567C	TCGA-A5-A0VP	UCEC	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R567C	TCGA-BH-A1F8	BRCA	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R567C	TCGA-CR-6491	HNSC	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R567C	DO1512	BRCA	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R567C	DO14192	HNSC	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R567C	DO42600	UCEC	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.I555M	TCGA-AC-A23H	BRCA	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.6507
p.I555M	DO2401	BRCA	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.6507
p.R543H	TCGA-CV-5441	HNSC	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R543H	DO15671	HNSC	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V554A	TCGA-CV-6961	HNSC	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.5825
p.V554A	DO14566	HNSC	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.5825
p.D553N	TCGA-FR-A726	SKCM	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.5821
p.D553N	DO48665	SKCM	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.5821
p.P548L	TCGA-GC-A3RB	BLCA	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P548L	DO530	BLCA	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R552G	TCGA-NJ-A55A	LUAD	TCGA	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.7568
p.R552G	DO218945	LUAD	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.7568
p.D553Y	DO234254	ESAD	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.6214
p.E566K	DO234388	ESAD	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E566K	DO228176	PBCA	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E566K	SIDM00451	T-Lymphoblastic Leukemia	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E566K	ACH-000937	Leukemia	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E566K	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R552W	DO228903	LICA	ICGC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.8634
p.H562N	SIDM00338	Acute Myeloid Leukemia	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.H562N	ACH-000439	Leukemia	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.H562N	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R542C	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R542C	ACH-002272	Lymphoma	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R542C	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I555V	SIDM01248	Thyroid Gland Carcinoma	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.5965
p.I555V	SIDM01167	Thyroid Gland Carcinoma	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.5965
p.I555V	ACH-000163	Thyroid Cancer	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.5965
p.I555V	ACH-001023	Thyroid Cancer	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.5965
p.I555V	CGTH-W-1	thyroid	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.5965
p.N546K	SIDM00445	Esophageal Carcinoma	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N546K	ACH-002292	Esophageal Cancer	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N546K	OACp4C	oesophagus	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N546K	NCI-H187	lung	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R543L	SIDM00927	Small Cell Lung Carcinoma	GDSC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R543L	ACH-000871	Lung Cancer	CCLE	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R543L	NCI-H510A	lung	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V552M	NCI-H740	lung	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.7208
p.K557N	NCI-H358	lung	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.6918
p.E565V	KP-2	pancreas	COSMIC	RDVIYEE	LIG_APCC_ABBAyCdc20_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RDVIYEE

Degron related mutations and impact score

Drug responses associated with SATB2 mutations

All proteins holding degron of RDVIYEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPW6	DNA-binding protein SATB2	LIG_APCC_ABBAyCdc20_2	552:558	RDVIYEE	APC,CDC20,FZR1	0.6733	More...