DegronMD

Uniprot ID: Q9UPW6

Source protein: DNA-binding protein SATB2

Source gene: SATB2

Class: DEG_SPOP_SBC_1

Location: 463:467

E3 ligase: SPOP

DEGRON score: 0.6389

ASA_SCORE: 86.48

COIL: 0.912

CONS_SCORE: 0.4119

DSS_SCORE: 0.6771

HELIX: 0.0308

FCONS_SCORE: 0.9478

RIG_SCORE: 0.6028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L472I	TCGA-73-A9RS	LUAD	TCGA	AKTST	DEG_SPOP_SBC_1	0.1944
p.L472I	DO51193	LUAD	ICGC	AKTST	DEG_SPOP_SBC_1	0.1944
p.D471Y	TCGA-85-A4JB	LUSC	TCGA	AKTST	DEG_SPOP_SBC_1	0.2222
p.D471Y	DO45517	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.2222
p.S453N	TCGA-D5-6930	COAD	TCGA	AKTST	DEG_SPOP_SBC_1	0.5
p.S453N	DO10550	COAD	ICGC	AKTST	DEG_SPOP_SBC_1	0.5
p.S466L	TCGA-EE-A2MC	SKCM	TCGA	AKTST	DEG_SPOP_SBC_1	0.7667
p.S466L	DO37559	SKCM	ICGC	AKTST	DEG_SPOP_SBC_1	0.7667
p.D477G	DO233747	GACA	ICGC	AKTST	DEG_SPOP_SBC_1	0.0556
p.K464E	DO231983	LICA	ICGC	AKTST	DEG_SPOP_SBC_1	0.591
p.D477E	DO228974	LICA	ICGC	AKTST	DEG_SPOP_SBC_1	0.0556
p.T469K	DO228974	LICA	ICGC	AKTST	DEG_SPOP_SBC_1	0.2778
p.P468T	DO229009	LICA	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P468L	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P468L	ACH-000667	Lung Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	0.3056
p.P468L	HCC-44	lung	COSMIC	AKTST	DEG_SPOP_SBC_1	0.3056
p.R459Q	SIDM00596	Endometrial Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.2222
p.R459Q	ACH-000941	Endometrial/Uterine Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	0.2222
p.R459Q	ACH-000954	Endometrial/Uterine Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	0.2222
p.R459Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	0.2222
p.R459Q	HEC-1	endometrium	COSMIC	AKTST	DEG_SPOP_SBC_1	0.2222
p.Q462R	SIDM00500	Colorectal Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.R463H	22RV1	prostate	COSMIC	AKTST	DEG_SPOP_SBC_1	0.8244
p.R473S	SF126	central_nervous_system	COSMIC	AKTST	DEG_SPOP_SBC_1	0.1667
p.S476F	WM-115	skin	COSMIC	AKTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SPOP_SBC_1	393:397	AKTST	SPOP	0.9928	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	710:714	AKTST	SPOP	0.9259	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_SPOP_SBC_1	2513:2517	AKTST	SPOP	0.973	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1743:1747	AKTST	SPOP	0.7173	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1912:1916	AKTST	SPOP	0.8233	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	1287:1291	AKTST	SPOP	0.9661	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10802:10806	AKTST	SPOP	0.9728	More...
Q9UPW6	DNA-binding protein SATB2	DEG_SPOP_SBC_1	463:467	AKTST	SPOP	0.6389	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons