DegronMD - P10636(MAPT)

GO - Biological processes (BP): activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; amyloid fibril formation [GO:1990000]; astrocyte activation [GO:0048143]; axonal transport [GO:0098930]; axonal transport of mitochondrion [GO:0019896]; axon development [GO:0061564]; cell-cell signaling [GO:0007267]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to heat [GO:0034605]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to reactive oxygen species [GO:0034614]; central nervous system neuron development [GO:0021954]; cytoplasmic microtubule organization [GO:0031122]; generation of neurons [GO:0048699]; internal protein amino acid acetylation [GO:0006475]; intracellular distribution of mitochondria [GO:0048312]; learning or memory [GO:0007611]; memory [GO:0007613]; microglial cell activation [GO:0001774]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; negative regulation of establishment of protein localization to mitochondrion [GO:1903748]; negative regulation of gene expression [GO:0010629]; negative regulation of kinase activity [GO:0033673]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of tubulin deacetylation [GO:1904428]; neurofibrillary tangle assembly [GO:1902988]; neuron projection development [GO:0031175]; plus-end-directed organelle transport along microtubule [GO:0072386]; positive regulation of axon extension [GO:0045773]; positive regulation of diacylglycerol kinase activity [GO:1905689]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuron death [GO:1901216]; positive regulation of protein localization [GO:1903829]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of superoxide anion generation [GO:0032930]; protein homooligomerization [GO:0051260]; protein polymerization [GO:0051258]; regulation of autophagy [GO:0010506]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cellular response to heat [GO:1900034]; regulation of chromosome organization [GO:0033044]; regulation of long-term synaptic depression [GO:1900452]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; regulation of mitochondrial fission [GO:0090140]; regulation of response to DNA damage stimulus [GO:2001020]; regulation of synaptic plasticity [GO:0048167]; response to lead ion [GO:0010288]; rRNA metabolic process [GO:0016072]; stress granule assembly [GO:0034063]; supramolecular fiber organization [GO:0097435]; synapse assembly [GO:0007416]; synapse organization [GO:0050808] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P493Q	TCGA-55-A4DG	LUAD	TCGA	PKTPPSS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.25
p.A430S	TCGA-64-1676	LUAD	TCGA	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.0556
p.A430S	DO23629	LUAD	ICGC	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.0556
p.G539V	TCGA-AP-A051	UCEC	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	545:552	Mutation rewiring degron network	0.1667
p.A118V	TCGA-AZ-4315	COAD	TCGA	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.25
p.A118V	DO8842	COAD	ICGC	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.25
p.D116E	TCGA-B6-A0RE	BRCA	TCGA	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.3056
p.D116E	DO3482	BRCA	ICGC	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.3056
p.P415L	TCGA-D3-A5GO	SKCM	TCGA	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation altering degron motif	0.6471
p.P415L	DO47419	SKCM	ICGC	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation altering degron motif	0.6471
p.P548S	TCGA-D9-A3Z4	SKCM	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	545:552	Mutation altering degron motif	0.6752
p.P548S	TCGA-IH-A3EA	SKCM	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	545:552	Mutation altering degron motif	0.6752
p.G385V	TCGA-EE-A29V	SKCM	TCGA	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1111
p.R544H	TCGA-EY-A1GK	UCEC	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	545:552	Mutation rewiring degron network	0.3056
p.R544H	SIDM00655	Other Solid Cancers	GDSC	VVRTPPKS	DEG_SCF_FBW7_1	545:552	Mutation rewiring degron network	0.3056
p.A430V	TCGA-EY-A1GQ	UCEC	TCGA	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.0556
p.A430V	DO43090	UCEC	ICGC	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.0556
p.P553Q	TCGA-FS-A1ZK	SKCM	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	545:552	Mutation rewiring degron network	0.3056
p.R546S	TCGA-G7-6795	KIRP	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	545:552	Mutation altering degron motif	0.7427
p.G387R	TCGA-GC-A6I3	BLCA	TCGA	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1667
p.E117K	TCGA-K4-A4AB	BLCA	TCGA	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.2778
p.E117K	DO44039	BLCA	ICGC	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.2778
p.P554H	TCGA-XF-AAN2	BLCA	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	545:552	Mutation blocking phosphorylation signal	0.7222
p.D387N	DO225346	BRCA	ICGC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1667
p.D387N	DO7828	COAD	ICGC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1667
p.D387N	DO40884	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1667
p.D387N	DO41020	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1667
p.G384C	DO222574	BTCA	ICGC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.0833
p.T396M	DO51607	CESC	ICGC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation altering degron motif	0.7423
p.E400K	DO233193	GACA	ICGC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.25
p.E400K	DO37966	SKCM	ICGC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.25
p.G384S	DO26710	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.0833
p.P98S	DO220906	MELA	ICGC	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.0556
p.A125T	DO222843	MELA	ICGC	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.0556
p.S427F	DO218838	SKCA	ICGC	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1389
p.S427F	SIDM00081	Melanoma	GDSC	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1389
p.S427F	SIDM01220	Glioma	GDSC	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1389
p.S427F	SIDM01504	Small Cell Lung Carcinoma	GDSC	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1389
p.S404A	DO41235	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1389
p.D389N	SIDM00193	Colorectal Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.2222
p.D389N	ACH-000991	Colon/Colorectal Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.2222
p.D389N	SNU-81	large intestine	COSMIC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.2222
p.S427P	SIDM00333	Endometrial Carcinoma	GDSC	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1389
p.R544L	SIDM00878	Breast Carcinoma	GDSC	VVRTPPKS	DEG_SCF_FBW7_1	545:552	Mutation rewiring degron network	0.3056
p.E125G	SIDM00683	Prostate Carcinoma	GDSC	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.0556
p.E125G	LNCaP-Clone-FGC	prostate	COSMIC	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.0556
p.P512S	SIDM01265	Plasma Cell Myeloma	GDSC	PKTPPSS	DEG_SCF_FBW7_1	496:502	Mutation blocking phosphorylation signal	0.5
p.L410F	SIDM00836	Colorectal Carcinoma	GDSC	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1944
p.L410F	SW403	large intestine	COSMIC	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1944
p.G107V	SIDM01757	Bladder Carcinoma	GDSC	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.3056
p.G107V	ACH-000741	Bladder Cancer	CCLE	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.3056
p.K405R	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation substituting flanking lysine	0.1667
p.K405R	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation substituting flanking lysine	0.2222
p.K405R	ACH-000158	Lymphoma	CCLE	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation substituting flanking lysine	0.1667
p.K405R	ACH-000158	Lymphoma	CCLE	AKTST	DEG_SPOP_SBC_1	393:397	Mutation substituting flanking lysine	0.2222
p.R511H	ACH-000928	Endometrial/Uterine Cancer	CCLE	PKTPPSS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.0833
p.R511H	ACH-000999	Colon/Colorectal Cancer	CCLE	PKTPPSS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.0833
p.R511H	ACH-001127	Leukemia	CCLE	PKTPPSS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.0833
p.R511H	SNU-1040	large intestine	COSMIC	PKTPPSS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.0833
p.R511H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PKTPPSS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.0833
p.R559H	ACH-000954	Endometrial/Uterine Cancer	CCLE	VVRTPPKS	DEG_SCF_FBW7_1	545:552	Mutation rewiring degron network	0.1389
p.R511C	ACH-002159	Skin Cancer	CCLE	PKTPPSS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.0833
p.R511C	M14	skin	COSMIC	PKTPPSS	DEG_SCF_FBW7_1	496:502	Mutation rewiring degron network	0.0833
p.G389V	SNU-1040	large intestine	COSMIC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.2222
p.H407R	PF-382	haematopoietic and lymphoid tissue	COSMIC	PTPGSS	DEG_SCF_FBW7_1	415:420	Mutation rewiring degron network	0.1111
p.H407R	PF-382	haematopoietic and lymphoid tissue	COSMIC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.0556
p.A110T	NCI-H1155	lung	COSMIC	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation altering degron motif	0.7139
p.S400C	JSC-1	haematopoietic and lymphoid tissue	COSMIC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.25
p.S404C	ChaGo-K-1	lung	COSMIC	AKTST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1389
p.T120M	NCI-H2342	lung	COSMIC	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.1944
p.D109N	SNU-81	large intestine	COSMIC	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation altering degron motif	0.6932
p.A100V	NALM-6	haematopoietic and lymphoid tissue	COSMIC	IGDTPSLE	DEG_SCF_FBW7_2	108:115	Mutation rewiring degron network	0.1111

Kaplan plot for MAPT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAPT

UniProt ID: P10636

Entrez ID: 4137

Protein name: Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAPT in