DegronMD

Uniprot ID: P10636

Source protein: Microtubule-associated protein tau

Source gene: MAPT

Class: DEG_SCF_FBW7_2

Location: 108:115

E3 ligase: FBXW7

DEGRON score: 0.5029

ASA_SCORE: 75.1875

COIL: 0.7705

CONS_SCORE: 0.3559

DSS_SCORE: 0.806

HELIX: 0.1889

FCONS_SCORE: 0.9714

RIG_SCORE: 0.6463

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A118V	TCGA-AZ-4315	COAD	TCGA	IGDTPSLE	DEG_SCF_FBW7_2	0.25
p.A118V	DO8842	COAD	ICGC	IGDTPSLE	DEG_SCF_FBW7_2	0.25
p.D116E	TCGA-B6-A0RE	BRCA	TCGA	IGDTPSLE	DEG_SCF_FBW7_2	0.3056
p.D116E	DO3482	BRCA	ICGC	IGDTPSLE	DEG_SCF_FBW7_2	0.3056
p.E117K	TCGA-K4-A4AB	BLCA	TCGA	IGDTPSLE	DEG_SCF_FBW7_2	0.2778
p.E117K	DO44039	BLCA	ICGC	IGDTPSLE	DEG_SCF_FBW7_2	0.2778
p.P98S	DO220906	MELA	ICGC	IGDTPSLE	DEG_SCF_FBW7_2	0.0556
p.A125T	DO222843	MELA	ICGC	IGDTPSLE	DEG_SCF_FBW7_2	0.0556
p.E125G	SIDM00683	Prostate Carcinoma	GDSC	IGDTPSLE	DEG_SCF_FBW7_2	0.0556
p.E125G	LNCaP-Clone-FGC	prostate	COSMIC	IGDTPSLE	DEG_SCF_FBW7_2	0.0556
p.G107V	SIDM01757	Bladder Carcinoma	GDSC	IGDTPSLE	DEG_SCF_FBW7_2	0.3056
p.G107V	ACH-000741	Bladder Cancer	CCLE	IGDTPSLE	DEG_SCF_FBW7_2	0.3056
p.A110T	NCI-H1155	lung	COSMIC	IGDTPSLE	DEG_SCF_FBW7_2	0.7139
p.T120M	NCI-H2342	lung	COSMIC	IGDTPSLE	DEG_SCF_FBW7_2	0.1944
p.D109N	SNU-81	large_intestine	COSMIC	IGDTPSLE	DEG_SCF_FBW7_2	0.6932
p.A100V	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	IGDTPSLE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SCF_FBW7_2	108:115	IGDTPSLE	FBXW7	0.5029	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons