DegronMD

Uniprot ID: P10636

Source protein: Microtubule-associated protein tau

Source gene: MAPT

Class: DEG_SCF_FBW7_1

Location: 545:552

E3 ligase: FBXW7

DEGRON score: 0.9942

ASA_SCORE: 111.5625

COIL: 0.9711

CONS_SCORE: 0.4567

DSS_SCORE: 0.7228

HELIX: 0.0115

FCONS_SCORE: 1.0129

RIG_SCORE: 0.6264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G539V	TCGA-AP-A051	UCEC	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	0.1667
p.P548S	TCGA-D9-A3Z4	SKCM	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	0.6752
p.P548S	TCGA-IH-A3EA	SKCM	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	0.6752
p.R544H	TCGA-EY-A1GK	UCEC	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	0.3056
p.R544H	SIDM00655	Other Solid Cancers	GDSC	VVRTPPKS	DEG_SCF_FBW7_1	0.3056
p.P553Q	TCGA-FS-A1ZK	SKCM	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	0.3056
p.R546S	TCGA-G7-6795	KIRP	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	0.7427
p.P554H	TCGA-XF-AAN2	BLCA	TCGA	VVRTPPKS	DEG_SCF_FBW7_1	0.7222
p.R544L	SIDM00878	Breast Carcinoma	GDSC	VVRTPPKS	DEG_SCF_FBW7_1	0.3056
p.R559H	ACH-000954	Endometrial/Uterine Cancer	CCLE	VVRTPPKS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SCF_FBW7_1	545:552	VVRTPPKS	FBXW7	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons