DegronMD

Uniprot ID: P10636

Source protein: Microtubule-associated protein tau

Source gene: MAPT

Class: DEG_SCF_FBW7_1

Location: 496:502

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 101.9857

COIL: 0.9704

CONS_SCORE: 0.4872

DSS_SCORE: 0.8663

HELIX: 0.0126

FCONS_SCORE: 1.1176

RIG_SCORE: 0.4757

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P493Q	TCGA-55-A4DG	LUAD	TCGA	PKTPPSS	DEG_SCF_FBW7_1	0.25
p.P512S	SIDM01265	Plasma Cell Myeloma	GDSC	PKTPPSS	DEG_SCF_FBW7_1	0.5
p.R511H	ACH-000928	Endometrial/Uterine Cancer	CCLE	PKTPPSS	DEG_SCF_FBW7_1	0.0833
p.R511H	ACH-000999	Colon/Colorectal Cancer	CCLE	PKTPPSS	DEG_SCF_FBW7_1	0.0833
p.R511H	ACH-001127	Leukemia	CCLE	PKTPPSS	DEG_SCF_FBW7_1	0.0833
p.R511H	SNU-1040	large_intestine	COSMIC	PKTPPSS	DEG_SCF_FBW7_1	0.0833
p.R511H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPPSS	DEG_SCF_FBW7_1	0.0833
p.R511C	ACH-002159	Skin Cancer	CCLE	PKTPPSS	DEG_SCF_FBW7_1	0.0833
p.R511C	M14	skin	COSMIC	PKTPPSS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SCF_FBW7_1	496:502	PKTPPSS	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons