DegronMD

Uniprot ID: P10636

Source protein: Microtubule-associated protein tau

Source gene: MAPT

Class: DEG_SCF_FBW7_1

Location: 415:420

E3 ligase: FBXW7

DEGRON score: 0.9661

ASA_SCORE: 86.5667

COIL: 0.9693

CONS_SCORE: 0.349

DSS_SCORE: 0.7121

HELIX: 0.012

FCONS_SCORE: 0.9153

RIG_SCORE: 0.5101

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A430S	TCGA-64-1676	LUAD	TCGA	PTPGSS	DEG_SCF_FBW7_1	0.0556
p.A430S	DO23629	LUAD	ICGC	PTPGSS	DEG_SCF_FBW7_1	0.0556
p.P415L	TCGA-D3-A5GO	SKCM	TCGA	PTPGSS	DEG_SCF_FBW7_1	0.6471
p.P415L	DO47419	SKCM	ICGC	PTPGSS	DEG_SCF_FBW7_1	0.6471
p.A430V	TCGA-EY-A1GQ	UCEC	TCGA	PTPGSS	DEG_SCF_FBW7_1	0.0556
p.A430V	DO43090	UCEC	ICGC	PTPGSS	DEG_SCF_FBW7_1	0.0556
p.S427F	DO218838	SKCA	ICGC	PTPGSS	DEG_SCF_FBW7_1	0.1389
p.S427F	SIDM00081	Melanoma	GDSC	PTPGSS	DEG_SCF_FBW7_1	0.1389
p.S427F	SIDM01220	Glioma	GDSC	PTPGSS	DEG_SCF_FBW7_1	0.1389
p.S427F	SIDM01504	Small Cell Lung Carcinoma	GDSC	PTPGSS	DEG_SCF_FBW7_1	0.1389
p.S427P	SIDM00333	Endometrial Carcinoma	GDSC	PTPGSS	DEG_SCF_FBW7_1	0.1389
p.L410F	SIDM00836	Colorectal Carcinoma	GDSC	PTPGSS	DEG_SCF_FBW7_1	0.1944
p.L410F	SW403	large_intestine	COSMIC	PTPGSS	DEG_SCF_FBW7_1	0.1944
p.K405R	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPGSS	DEG_SCF_FBW7_1	0.1667
p.K405R	ACH-000158	Lymphoma	CCLE	PTPGSS	DEG_SCF_FBW7_1	0.1667
p.H407R	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGSS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SCF_FBW7_1	415:420	PTPGSS	FBXW7	0.9661	More...
Q8IX07	Zinc finger protein ZFPM1	DEG_SCF_FBW7_1	507:512	PTPGSS	FBXW7	0.9987	More...
Q8N2Y8	AP-4 complex accessory subunit RUSC2	DEG_SCF_FBW7_1	1509:1514	PTPGSS	FBXW7	0.7028	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons