DegronMD

Uniprot ID: Q8IX07

Source protein: Zinc finger protein ZFPM1

Source gene: ZFPM1

Class: DEG_SCF_FBW7_1

Location: 507:512

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 81.0167

COIL: 0.9675

CONS_SCORE: 0.4757

DSS_SCORE: 0.6079

HELIX: 0.0107

FCONS_SCORE: 1.3126

RIG_SCORE: 0.5266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A502T	DO224645	COCA	ICGC	PTPGSS	DEG_SCF_FBW7_1	0.1944
p.G522R	DO234404	ESAD	ICGC	PTPGSS	DEG_SCF_FBW7_1	0.0556
p.G510D	DO23440	LINC	ICGC	PTPGSS	DEG_SCF_FBW7_1	0.6087
p.R499G	ACH-001289	Rhabdoid	CCLE	PTPGSS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SCF_FBW7_1	415:420	PTPGSS	FBXW7	0.9661	More...
Q8IX07	Zinc finger protein ZFPM1	DEG_SCF_FBW7_1	507:512	PTPGSS	FBXW7	0.9987	More...
Q8N2Y8	AP-4 complex accessory subunit RUSC2	DEG_SCF_FBW7_1	1509:1514	PTPGSS	FBXW7	0.7028	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons