DegronMD - Q8N2Y8(RUSC2)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1492N	TCGA-78-7540	LUAD	TCGA	VTLTPTPS	DEG_SCF_FBW7_1	1501:1508	Mutation rewiring degron network	0.0833
p.D1492N	DO233903	GACA	ICGC	VTLTPTPS	DEG_SCF_FBW7_1	1501:1508	Mutation rewiring degron network	0.0833
p.D1492N	DO23810	LUAD	ICGC	VTLTPTPS	DEG_SCF_FBW7_1	1501:1508	Mutation rewiring degron network	0.0833
p.R79L	TCGA-A8-A09R	BRCA	TCGA	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.2778
p.R79L	DO3542	BRCA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.2778
p.D82N	TCGA-C5-A7UH	CESC	TCGA	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.1944
p.D82N	DO49891	CESC	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.1944
p.P1511S	TCGA-D3-A1QB	SKCM	TCGA	PTPGSS	DEG_SCF_FBW7_1	1509:1514	Mutation altering degron motif	0.6752
p.P1511S	DO47573	SKCM	ICGC	PTPGSS	DEG_SCF_FBW7_1	1509:1514	Mutation altering degron motif	0.6752
p.S1493F	TCGA-G2-A2EJ	BLCA	TCGA	VTLTPTPS	DEG_SCF_FBW7_1	1501:1508	Mutation rewiring degron network	0.1111
p.S1493F	DO554	BLCA	ICGC	VTLTPTPS	DEG_SCF_FBW7_1	1501:1508	Mutation rewiring degron network	0.1111
p.P1509S	DO222798	COCA	ICGC	PTPGSS	DEG_SCF_FBW7_1	1509:1514	Mutation altering degron motif	0.6752
p.T73A	DO229010	COCA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.7139
p.T73A	DO229013	COCA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.7139
p.T73A	DO229016	COCA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.7139
p.T73A	DO229003	COCA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.7139
p.T73A	DO229005	COCA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.7139
p.G76V	DO228948	LICA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation altering degron motif	0.6421
p.S83I	DO229029	LICA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.1667
p.S1514I	DO229037	LICA	ICGC	PTPGSS	DEG_SCF_FBW7_1	1509:1514	Mutation altering degron motif	0.7341
p.R79W	SIDM00449	B-Lymphoblastic Leukemia	GDSC	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.2778
p.R79W	ACH-000922	Leukemia	CCLE	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.2778
p.R79W	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.2778
p.S69N	ACH-000950	Colon/Colorectal Cancer	CCLE	LHSTPGGT	DEG_SCF_FBW7_1	70:77	Mutation rewiring degron network	0.3056

Kaplan plot for RUSC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RUSC2

UniProt ID: Q8N2Y8

Entrez ID: 9853

Protein name: AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RUSC2 in