DegronMD

Uniprot ID: Q8N2Y8

Source protein: AP-4 complex accessory subunit RUSC2

Source gene: RUSC2

Class: DEG_SCF_FBW7_1

Location: 1501:1508

E3 ligase: FBXW7

DEGRON score: 0.5258

ASA_SCORE: 65.375

COIL: 0.6031

CONS_SCORE: 0.4929

DSS_SCORE: 0.5405

HELIX: 0.0034

FCONS_SCORE: 0.9019

RIG_SCORE: 0.695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1492N	TCGA-78-7540	LUAD	TCGA	VTLTPTPS	DEG_SCF_FBW7_1	0.0833
p.D1492N	DO233903	GACA	ICGC	VTLTPTPS	DEG_SCF_FBW7_1	0.0833
p.D1492N	DO23810	LUAD	ICGC	VTLTPTPS	DEG_SCF_FBW7_1	0.0833
p.S1493F	TCGA-G2-A2EJ	BLCA	TCGA	VTLTPTPS	DEG_SCF_FBW7_1	0.1111
p.S1493F	DO554	BLCA	ICGC	VTLTPTPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N2Y8	AP-4 complex accessory subunit RUSC2	DEG_SCF_FBW7_1	1501:1508	VTLTPTPS	FBXW7	0.5258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons