DegronMD

Uniprot ID: Q8N2Y8

Source protein: AP-4 complex accessory subunit RUSC2

Source gene: RUSC2

Class: DEG_SCF_FBW7_1

Location: 1509:1514

E3 ligase: FBXW7

DEGRON score: 0.7028

ASA_SCORE: 90.8833

COIL: 0.9735

CONS_SCORE: 0.294

DSS_SCORE: 0.8856

HELIX: 0.0138

FCONS_SCORE: 0.5839

RIG_SCORE: 0.5663

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1511S	TCGA-D3-A1QB	SKCM	TCGA	PTPGSS	DEG_SCF_FBW7_1	0.6752
p.P1511S	DO47573	SKCM	ICGC	PTPGSS	DEG_SCF_FBW7_1	0.6752
p.P1509S	DO222798	COCA	ICGC	PTPGSS	DEG_SCF_FBW7_1	0.6752
p.S1514I	DO229037	LICA	ICGC	PTPGSS	DEG_SCF_FBW7_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SCF_FBW7_1	415:420	PTPGSS	FBXW7	0.9661	More...
Q8IX07	Zinc finger protein ZFPM1	DEG_SCF_FBW7_1	507:512	PTPGSS	FBXW7	0.9987	More...
Q8N2Y8	AP-4 complex accessory subunit RUSC2	DEG_SCF_FBW7_1	1509:1514	PTPGSS	FBXW7	0.7028	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons