DegronMD

Uniprot ID: Q8N2Y8

Source protein: AP-4 complex accessory subunit RUSC2

Source gene: RUSC2

Class: DEG_SCF_FBW7_1

Location: 70:77

E3 ligase: FBXW7

DEGRON score: 0.9686

ASA_SCORE: 77.175

COIL: 0.844

CONS_SCORE: 0.3367

DSS_SCORE: 0.5839

HELIX: 0.0723

FCONS_SCORE: 0.9255

RIG_SCORE: 0.5906

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R79L	TCGA-A8-A09R	BRCA	TCGA	LHSTPGGT	DEG_SCF_FBW7_1	0.2778
p.R79L	DO3542	BRCA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	0.2778
p.D82N	TCGA-C5-A7UH	CESC	TCGA	LHSTPGGT	DEG_SCF_FBW7_1	0.1944
p.D82N	DO49891	CESC	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	0.1944
p.T73A	DO229010	COCA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	0.7139
p.T73A	DO229013	COCA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	0.7139
p.T73A	DO229016	COCA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	0.7139
p.T73A	DO229003	COCA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	0.7139
p.T73A	DO229005	COCA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	0.7139
p.G76V	DO228948	LICA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	0.6421
p.S83I	DO229029	LICA	ICGC	LHSTPGGT	DEG_SCF_FBW7_1	0.1667
p.R79W	SIDM00449	B-Lymphoblastic Leukemia	GDSC	LHSTPGGT	DEG_SCF_FBW7_1	0.2778
p.R79W	ACH-000922	Leukemia	CCLE	LHSTPGGT	DEG_SCF_FBW7_1	0.2778
p.R79W	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	LHSTPGGT	DEG_SCF_FBW7_1	0.2778
p.S69N	ACH-000950	Colon/Colorectal Cancer	CCLE	LHSTPGGT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N2Y8	AP-4 complex accessory subunit RUSC2	DEG_SCF_FBW7_1	70:77	LHSTPGGT	FBXW7	0.9686	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons