DegronMD

Uniprot ID: P10636

Source protein: Microtubule-associated protein tau

Source gene: MAPT

Class: DEG_SPOP_SBC_1

Location: 393:397

E3 ligase: SPOP

DEGRON score: 0.9928

ASA_SCORE: 89.66

COIL: 0.9302

CONS_SCORE: 0.4105

DSS_SCORE: 0.6879

HELIX: 0.0272

FCONS_SCORE: 1.0788

RIG_SCORE: 0.6366

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G385V	TCGA-EE-A29V	SKCM	TCGA	AKTST	DEG_SPOP_SBC_1	0.1111
p.G387R	TCGA-GC-A6I3	BLCA	TCGA	AKTST	DEG_SPOP_SBC_1	0.1667
p.D387N	DO225346	BRCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.D387N	DO7828	COAD	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.D387N	DO40884	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.D387N	DO41020	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.G384C	DO222574	BTCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.0833
p.T396M	DO51607	CESC	ICGC	AKTST	DEG_SPOP_SBC_1	0.7423
p.E400K	DO233193	GACA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.E400K	DO37966	SKCM	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.G384S	DO26710	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.0833
p.S404A	DO41235	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	0.1389
p.D389N	SIDM00193	Colorectal Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.2222
p.D389N	ACH-000991	Colon/Colorectal Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	0.2222
p.D389N	SNU-81	large_intestine	COSMIC	AKTST	DEG_SPOP_SBC_1	0.2222
p.K405R	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.2222
p.K405R	ACH-000158	Lymphoma	CCLE	AKTST	DEG_SPOP_SBC_1	0.2222
p.G389V	SNU-1040	large_intestine	COSMIC	AKTST	DEG_SPOP_SBC_1	0.2222
p.H407R	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	AKTST	DEG_SPOP_SBC_1	0.0556
p.S400C	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	AKTST	DEG_SPOP_SBC_1	0.25
p.S404C	ChaGo-K-1	lung	COSMIC	AKTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SPOP_SBC_1	393:397	AKTST	SPOP	0.9928	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	710:714	AKTST	SPOP	0.9259	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_SPOP_SBC_1	2513:2517	AKTST	SPOP	0.973	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1743:1747	AKTST	SPOP	0.7173	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1912:1916	AKTST	SPOP	0.8233	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	1287:1291	AKTST	SPOP	0.9661	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10802:10806	AKTST	SPOP	0.9728	More...
Q9UPW6	DNA-binding protein SATB2	DEG_SPOP_SBC_1	463:467	AKTST	SPOP	0.6389	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons