DegronMD

Uniprot ID: Q7RTP6

Source protein: [F-actin]-monooxygenase MICAL3

Source gene: MICAL3

Class: DEG_SPOP_SBC_1

Location: 1287:1291

E3 ligase: SPOP

DEGRON score: 0.9661

ASA_SCORE: 92.68

COIL: 0.9334

CONS_SCORE: 0.448

DSS_SCORE: 0.6625

HELIX: 0.0186

FCONS_SCORE: 1.0232

RIG_SCORE: 0.627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1281C	TCGA-44-2657	LUAD	TCGA	AKTST	DEG_SPOP_SBC_1	0.1667
p.R1281C	DO233884	GACA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.R1281C	DO25020	LUAD	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.R1281C	DO35083	PACA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.R1281H	DO229375	BTCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.R1281H	SIDM00168	Head and Neck Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.1667
p.R1281H	ACH-000549	Head and Neck Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	0.1667
p.P1286L	SIDM00305	Ovarian Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM00434	Plasma Cell Myeloma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM00232	Kidney Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM01040	Ovarian Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM00064	Hepatocellular Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM00291	Melanoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM00995	Other Solid Cancers	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM00054	Pancreatic Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM00498	Colorectal Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM00970	Bladder Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM00604	Oral Cavity Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM00273	Glioblastoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM01173	Rhabdomyosarcoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM01460	Glioma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1286L	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.R1281S	ACH-000744	Lung Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	0.1667
p.R1281S	NCI-H1623	lung	COSMIC	AKTST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SPOP_SBC_1	393:397	AKTST	SPOP	0.9928	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	710:714	AKTST	SPOP	0.9259	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_SPOP_SBC_1	2513:2517	AKTST	SPOP	0.973	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1743:1747	AKTST	SPOP	0.7173	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1912:1916	AKTST	SPOP	0.8233	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	1287:1291	AKTST	SPOP	0.9661	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10802:10806	AKTST	SPOP	0.9728	More...
Q9UPW6	DNA-binding protein SATB2	DEG_SPOP_SBC_1	463:467	AKTST	SPOP	0.6389	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKTST

Degron related mutations and impact score

Drug responses associated with MICAL3 mutations

All proteins holding degron of AKTST