DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SPOP_SBC_1

Location: 1912:1916

E3 ligase: SPOP

DEGRON score: 0.8233

ASA_SCORE: 92.66

COIL: 0.8598

CONS_SCORE: 0.3162

DSS_SCORE: 0.6033

HELIX: 0.0178

FCONS_SCORE: 1.0748

RIG_SCORE: 0.6051

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1914A	TCGA-85-8355	LUSC	TCGA	AKTST	DEG_SPOP_SBC_1	0.7139
p.T1914A	DO45488	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.7139
p.S1915A	TCGA-A8-A07O	BRCA	TCGA	AKTST	DEG_SPOP_SBC_1	0.7588
p.S1915A	DO1277	BRCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.7588
p.S1915C	TCGA-CQ-7071	HNSC	TCGA	AKTST	DEG_SPOP_SBC_1	0.7541
p.S1915C	DO49069	HNSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.7541
p.Y1920S	DO48395	BLCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.2222
p.Y1920S	DO48385	BLCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.2222
p.Y1920S	DO48390	BLCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.2222
p.Y1920S	DO48377	BLCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.2222
p.Y1920S	DO48370	BLCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.2222
p.Y1920S	DO48432	BLCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.2222
p.P1906L	DO224668	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.P1906L	DO229010	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.P1906L	DO229016	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.P1906L	DO229003	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.P1906L	DO229005	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.T1922I	DO224817	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.T1922I	DO222800	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.T1911M	DO222785	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1911M	DO222793	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1911M	DO222866	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1911M	DO222826	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1911M	DO229016	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1911M	DO229005	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1911M	DO51006	LAML	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1911M	DO52364	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1911M	DO52359	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.P1919H	DO229010	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.P1919H	DO229013	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.P1919H	DO229016	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.P1919H	DO229003	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.P1919H	DO229005	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.P1919H	DO52379	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.P1919H	DO52345	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.P1919H	DO52388	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.P1919H	DO52383	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.S1905F	DO220907	MELA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1389
p.L1918I	SIDM00789	Colorectal Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.2778
p.L1918I	HCT-15	large_intestine	COSMIC	AKTST	DEG_SPOP_SBC_1	0.2778
p.S1915F	SIDM00630	Breast Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7982
p.S1915F	MDA-MB-415	breast	COSMIC	AKTST	DEG_SPOP_SBC_1	0.7982
p.S1908L	SIDM00097	Breast Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.6667
p.S1908L	T47D	breast	COSMIC	AKTST	DEG_SPOP_SBC_1	0.6667
p.Q1904K	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.1111
p.Q1904K	NCI-H1666	lung	COSMIC	AKTST	DEG_SPOP_SBC_1	0.1111
p.S1903R	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.0833
p.S1903R	NCI-H1666	lung	COSMIC	AKTST	DEG_SPOP_SBC_1	0.0833
p.S1917P	RCC-ER	kidney	COSMIC	AKTST	DEG_SPOP_SBC_1	0.3056
p.S1917P	COR-L105	lung	COSMIC	AKTST	DEG_SPOP_SBC_1	0.3056
p.S1905A	NCI-H1092	lung	COSMIC	AKTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SPOP_SBC_1	393:397	AKTST	SPOP	0.9928	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	710:714	AKTST	SPOP	0.9259	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_SPOP_SBC_1	2513:2517	AKTST	SPOP	0.973	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1743:1747	AKTST	SPOP	0.7173	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1912:1916	AKTST	SPOP	0.8233	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	1287:1291	AKTST	SPOP	0.9661	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10802:10806	AKTST	SPOP	0.9728	More...
Q9UPW6	DNA-binding protein SATB2	DEG_SPOP_SBC_1	463:467	AKTST	SPOP	0.6389	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKTST

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of AKTST