DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SPOP_SBC_1

Location: 1743:1747

E3 ligase: SPOP

DEGRON score: 0.7173

ASA_SCORE: 92.88

COIL: 0.848

CONS_SCORE: 0.2421

DSS_SCORE: 0.6195

HELIX: 0.0328

FCONS_SCORE: 0.8391

RIG_SCORE: 0.6016

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1745A	TCGA-BP-4801	KIRC	TCGA	AKTST	DEG_SPOP_SBC_1	0.7139
p.T1745A	DO18066	KIRC	ICGC	AKTST	DEG_SPOP_SBC_1	0.7139
p.H1752Y	TCGA-BR-4292	STAD	TCGA	AKTST	DEG_SPOP_SBC_1	0.1944
p.H1752Y	DO38495	STAD	ICGC	AKTST	DEG_SPOP_SBC_1	0.1944
p.S1736F	TCGA-D3-A8GB	SKCM	TCGA	AKTST	DEG_SPOP_SBC_1	0.1389
p.S1736F	DO50280	SKCM	ICGC	AKTST	DEG_SPOP_SBC_1	0.1389
p.T1742K	TCGA-FF-A7CR	DLBC	TCGA	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1742K	DO219894	DLBC	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1742M	TCGA-SX-A7SL	KIRP	TCGA	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1742M	DO49783	KIRP	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1742M	SIDM01278	Colorectal Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.Q1735H	DO228483	BRCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1111
p.Q1735H	DO224772	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1111
p.Q1735H	DO224808	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1111
p.Q1735H	DO222894	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1111
p.Q1735H	DO222829	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1111
p.Q1735H	DO229003	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1111
p.Q1735H	DO229346	LAML	ICGC	AKTST	DEG_SPOP_SBC_1	0.1111
p.Q1735H	DO50986	LAML	ICGC	AKTST	DEG_SPOP_SBC_1	0.1111
p.Q1735H	DO52369	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.1111
p.Q1735H	DO229467	SKCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1111
p.H1750R	DO228483	BRCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.H1750R	DO224685	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.H1750R	DO224808	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.H1750R	DO224817	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.H1750R	DO222894	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.H1750R	DO229013	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.H1750R	DO229003	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.H1750R	DO229346	LAML	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.H1750R	DO51031	LAML	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.H1750R	DO52389	LUSC	ICGC	AKTST	DEG_SPOP_SBC_1	0.25
p.R1737P	DO224726	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.R1737P	DO224735	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.R1737P	DO224801	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.R1737P	DO222782	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.S1736A	DO224744	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1389
p.A1743G	DO224801	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.754
p.Q1735P	DO224801	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1111
p.R1737G	DO224801	COCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.A1743T	DO233935	GACA	ICGC	AKTST	DEG_SPOP_SBC_1	0.7139
p.A1743T	SIDM00933	Breast Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7139
p.A1743T	SIDM01090	Colorectal Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7139
p.A1743T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7139
p.A1743T	SIDM01117	Small Cell Lung Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7139
p.A1743T	SIDM00971	Breast Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7139
p.A1743T	SIDM00493	Other Solid Cancers	GDSC	AKTST	DEG_SPOP_SBC_1	0.7139
p.A1743T	SIDM00254	Neuroblastoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7139
p.A1743T	SIDM00875	Breast Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7139
p.A1743T	SIDM01147	Gastric Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7139
p.A1743T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7139
p.A1743T	SIDM00721	Small Cell Lung Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7139
p.A1743T	SIDM01173	Rhabdomyosarcoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7139
p.S1734N	DO232052	ORCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.0833
p.T1753I	DO232681	PBCA	ICGC	AKTST	DEG_SPOP_SBC_1	0.1667
p.H1750N	SIDM00492	Glioblastoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.25
p.T1742A	SIDM00251	Gastric Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.3056
p.T1747K	SIDM00665	Gastric Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	0.7306
p.T1747K	ACH-000616	Gastric Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SPOP_SBC_1	393:397	AKTST	SPOP	0.9928	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	710:714	AKTST	SPOP	0.9259	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_SPOP_SBC_1	2513:2517	AKTST	SPOP	0.973	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1743:1747	AKTST	SPOP	0.7173	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1912:1916	AKTST	SPOP	0.8233	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	1287:1291	AKTST	SPOP	0.9661	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10802:10806	AKTST	SPOP	0.9728	More...
Q9UPW6	DNA-binding protein SATB2	DEG_SPOP_SBC_1	463:467	AKTST	SPOP	0.6389	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKTST

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of AKTST