DegronMD

Uniprot ID: P27816

Source protein: Microtubule-associated protein 4

Source gene: MAP4

Class: DEG_SPOP_SBC_1

Location: 710:714

E3 ligase: SPOP

DEGRON score: 0.9259

ASA_SCORE: 99.44

COIL: 0.9406

CONS_SCORE: 0.5387

DSS_SCORE: 0.7559

HELIX: 0.0296

FCONS_SCORE: 0.9441

RIG_SCORE: 0.6255

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K718R	TCGA-97-A4LX	LUAD	TCGA	AKTST	DEG_SPOP_SBC_1	0.3333
p.K718R	DO218934	LUAD	ICGC	AKTST	DEG_SPOP_SBC_1	0.3333
p.S715L	TCGA-AX-A06F	UCEC	TCGA	AKTST	DEG_SPOP_SBC_1	0.3056
p.S715L	TCGA-EE-A2GC	SKCM	TCGA	AKTST	DEG_SPOP_SBC_1	0.3056
p.S715L	DO37839	SKCM	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.S715L	DO41752	UCEC	ICGC	AKTST	DEG_SPOP_SBC_1	0.3056
p.Q708E	TCGA-EK-A2RJ	CESC	TCGA	AKTST	DEG_SPOP_SBC_1	0.2778
p.Q708E	DO49950	CESC	ICGC	AKTST	DEG_SPOP_SBC_1	0.2778
p.R705C	DO234168	ESAD	ICGC	AKTST	DEG_SPOP_SBC_1	0.1944
p.P712T	DO229045	LICA	ICGC	AKTST	DEG_SPOP_SBC_1	0.7031
p.T706A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	AKTST	DEG_SPOP_SBC_1	0.6667
p.T706A	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	AKTST	DEG_SPOP_SBC_1	0.6667
p.G714R	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	AKTST	DEG_SPOP_SBC_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10636	Microtubule-associated protein tau	DEG_SPOP_SBC_1	393:397	AKTST	SPOP	0.9928	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	710:714	AKTST	SPOP	0.9259	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_SPOP_SBC_1	2513:2517	AKTST	SPOP	0.973	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1743:1747	AKTST	SPOP	0.7173	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1912:1916	AKTST	SPOP	0.8233	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	1287:1291	AKTST	SPOP	0.9661	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10802:10806	AKTST	SPOP	0.9728	More...
Q9UPW6	DNA-binding protein SATB2	DEG_SPOP_SBC_1	463:467	AKTST	SPOP	0.6389	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons