DegronMD - Q7RTP6(MICAL3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T867S	TCGA-28-2506	GBM	TCGA	VASST	DEG_SPOP_SBC_1	860:864	Mutation blocking phosphorylation signal	0.6944
p.T867S	TCGA-Y8-A898	KIRP	TCGA	VASST	DEG_SPOP_SBC_1	860:864	Mutation blocking phosphorylation signal	0.6944
p.T867S	DO11585	GBM	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation blocking phosphorylation signal	0.6944
p.T867S	DO49804	KIRP	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation blocking phosphorylation signal	0.6944
p.R1281C	TCGA-44-2657	LUAD	TCGA	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1667
p.R1281C	TCGA-44-2657	LUAD	TCGA	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1667
p.R1281C	DO233884	GACA	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1667
p.R1281C	DO233884	GACA	ICGC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1667
p.R1281C	DO25020	LUAD	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1667
p.R1281C	DO25020	LUAD	ICGC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1667
p.R1281C	DO35083	PACA	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1667
p.R1281C	DO35083	PACA	ICGC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1667
p.N477S	TCGA-63-A5MY	LUSC	TCGA	NFSQYSIDP	CBL_PTK	459:467	Mutation rewiring degron network	0.0556
p.N477S	DO219171	LUSC	ICGC	NFSQYSIDP	CBL_PTK	459:467	Mutation rewiring degron network	0.0556
p.I1260M	TCGA-77-8136	LUSC	TCGA	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1389
p.I1260M	DO26593	LUSC	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1389
p.I1260M	DO228014	SKCA	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1389
p.R470Q	TCGA-A5-A0G2	UCEC	TCGA	NFSQYSIDP	CBL_PTK	459:467	Mutation rewiring degron network	0.25
p.R470Q	DO41235	UCEC	ICGC	NFSQYSIDP	CBL_PTK	459:467	Mutation rewiring degron network	0.25
p.N459K	TCGA-A5-A1OF	UCEC	TCGA	NFSQYSIDP	CBL_PTK	459:467	Mutation altering degron motif	0.6918
p.N459K	DO42568	UCEC	ICGC	NFSQYSIDP	CBL_PTK	459:467	Mutation altering degron motif	0.6918
p.E945D	TCGA-BG-A222	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.0556
p.E945D	DO42977	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.0556
p.A857V	TCGA-CG-4442	STAD	TCGA	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.25
p.A857V	DO232761	PBCA	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.25
p.A857V	DO38380	STAD	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.25
p.P1559L	TCGA-CG-5733	STAD	TCGA	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.25
p.P1559L	DO38551	STAD	ICGC	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.25
p.P1259T	TCGA-CN-6997	HNSC	TCGA	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1111
p.P1259T	DO14414	HNSC	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1111
p.E865K	TCGA-CQ-5333	HNSC	TCGA	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.3056
p.E865K	DO14218	HNSC	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.3056
p.D466N	TCGA-D1-A103	UCEC	TCGA	NFSQYSIDP	CBL_PTK	459:467	Mutation altering degron motif	0.5821
p.D466N	DO42312	UCEC	ICGC	NFSQYSIDP	CBL_PTK	459:467	Mutation altering degron motif	0.5821
p.R856Q	TCGA-D7-8576	STAD	TCGA	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.2222
p.R856Q	DO47977	STAD	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.2222
p.P453H	TCGA-DA-A1I1	SKCM	TCGA	NFSQYSIDP	CBL_PTK	459:467	Mutation rewiring degron network	0.1667
p.P453H	DO37966	SKCM	ICGC	NFSQYSIDP	CBL_PTK	459:467	Mutation rewiring degron network	0.1667
p.V860M	TCGA-DD-AACZ	LIHC	TCGA	VASST	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7208
p.V860M	DO52216	LIHC	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7208
p.V860M	SIDM00188	Kidney Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7208
p.V860M	SIDM00313	Hodgkin's Lymphoma	GDSC	VASST	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7208
p.V860M	SIDM01711	Non-Cancerous	GDSC	VASST	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7208
p.V860M	SIDM01059	Melanoma	GDSC	VASST	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7208
p.E1572K	TCGA-EE-A20C	SKCM	TCGA	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.1667
p.E1572K	DO222775	MELA	ICGC	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.1667
p.E1572K	DO47665	SKCM	ICGC	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.1667
p.Q1265K	TCGA-EE-A29B	SKCM	TCGA	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.2778
p.Q1265K	DO47255	SKCM	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.2778
p.S1274F	TCGA-EE-A2MS	SKCM	TCGA	STEATVPSP	DEG_COP1_1	1267:1275	Mutation altering degron motif	0.9093
p.S1274F	DO37567	SKCM	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation altering degron motif	0.9093
p.T925M	TCGA-F5-6814	READ	TCGA	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1667
p.T925M	DO36556	READ	ICGC	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1667
p.Q1263K	TCGA-FS-A1ZM	SKCM	TCGA	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.2222
p.Q1263K	DO37731	SKCM	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.2222
p.P1559Q	TCGA-FS-A1ZQ	SKCM	TCGA	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.25
p.P1559Q	DO37442	SKCM	ICGC	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.25
p.D852G	TCGA-Q1-A5R3	CESC	TCGA	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1111
p.D852G	DO49008	CESC	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1111
p.D852G	SIDM00889	Cervical Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1111
p.D852G	ACH-001333	Cervical Cancer	CCLE	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1111
p.D852G	C-33-A	cervix	COSMIC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1111
p.E1554K	TCGA-SY-A9G5	BLCA	TCGA	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.1111
p.E1554K	DO51906	BLCA	ICGC	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.1111
p.K458N	TCGA-UY-A9PB	BLCA	TCGA	NFSQYSIDP	CBL_PTK	459:467	Mutation rewiring degron network	0.3056
p.K458N	DO219041	BLCA	ICGC	NFSQYSIDP	CBL_PTK	459:467	Mutation rewiring degron network	0.3056
p.P1264L	TCGA-WE-A8ZX	SKCM	TCGA	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.25
p.P1264L	DO51291	SKCM	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.25
p.T1276I	DO228483	BRCA	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation blocking phosphorylation signal	0.75
p.T1276I	DO52346	LUSC	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation blocking phosphorylation signal	0.75
p.R1281H	DO229375	BTCA	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1667
p.R1281H	DO229375	BTCA	ICGC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1667
p.R1281H	SIDM00168	Head and Neck Carcinoma	GDSC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1667
p.R1281H	SIDM00168	Head and Neck Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1667
p.R1281H	ACH-000549	Head and Neck Cancer	CCLE	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1667
p.R1281H	ACH-000549	Head and Neck Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1667
p.G1566E	DO227987	COCA	ICGC	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation altering degron motif	0.6087
p.S1442G	DO233942	GACA	ICGC	MLTPPSS	DEG_SCF_FBW7_1	1452:1458	Mutation rewiring degron network	0.0556
p.V945I	DO233944	GACA	ICGC	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.0556
p.W936L	DO228284	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.3056
p.Q1576L	DO228934	LICA	ICGC	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.0556
p.T1574M	DO228983	LICA	ICGC	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation blocking phosphorylation signal	0.5556
p.P467T	DO229038	LICA	ICGC	NFSQYSIDP	CBL_PTK	459:467	Mutation altering degron motif	0.7031
p.Q855E	DO45448	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1944
p.S1262F	DO228537	MALY	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation blocking phosphorylation signal	0.6389
p.S1262F	DO218855	SKCA	ICGC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation blocking phosphorylation signal	0.6389
p.A859V	DO220886	MELA	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.3056
p.S921I	DO50682	ORCA	ICGC	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.0556
p.G874C	DO27933	ORCA	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.0556
p.N854D	DO38815	STAD	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1667
p.H1558P	DO229144	THCA	ICGC	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.2222
p.H1558P	ACH-000970	Colon/Colorectal Cancer	CCLE	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.2222
p.S1457Y	DO229257	THCA	ICGC	MLTPPSS	DEG_SCF_FBW7_1	1452:1458	Mutation altering degron motif	0.712
p.P1460S	DO229242	THCA	ICGC	MLTPPSS	DEG_SCF_FBW7_1	1452:1458	Mutation rewiring degron network	0.2778
p.P1460S	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	MLTPPSS	DEG_SCF_FBW7_1	1452:1458	Mutation rewiring degron network	0.2778
p.P1460S	ACH-000980	Lung Cancer	CCLE	MLTPPSS	DEG_SCF_FBW7_1	1452:1458	Mutation rewiring degron network	0.2778
p.L865I	DO41999	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.3056
p.P1286L	SIDM00305	Ovarian Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM00434	Plasma Cell Myeloma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM00232	Kidney Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM01040	Ovarian Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM00064	Hepatocellular Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM00291	Melanoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM00995	Other Solid Cancers	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM00054	Pancreatic Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM00498	Colorectal Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM00970	Bladder Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM00604	Oral Cavity Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM00273	Glioblastoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM01173	Rhabdomyosarcoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM01460	Glioma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.P1286L	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.E850D	SIDM01151	Hepatocellular Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.0556
p.E850D	SNU-182	liver	COSMIC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.0556
p.A864T	SIDM00845	Burkitt's Lymphoma	GDSC	VASST	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7139
p.A864T	SIDM00461	Acute Myeloid Leukemia	GDSC	VASST	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7139
p.A864T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VASST	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7139
p.P1461T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	MLTPPSS	DEG_SCF_FBW7_1	1452:1458	Mutation rewiring degron network	0.25
p.L865R	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.3056
p.L865R	NCI-H1703	lung	COSMIC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.3056
p.T1454K	SIDM00951	T-Lymphoblastic Leukemia	GDSC	MLTPPSS	DEG_SCF_FBW7_1	1452:1458	Mutation altering degron motif	0.8417
p.T1454K	CTV-1	haematopoietic and lymphoid tissue	COSMIC	MLTPPSS	DEG_SCF_FBW7_1	1452:1458	Mutation altering degron motif	0.8417
p.C1261Y	SIDM00951	T-Lymphoblastic Leukemia	GDSC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1667
p.C1261Y	ACH-002222	Leukemia	CCLE	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1667
p.C1261Y	CTV-1	haematopoietic and lymphoid tissue	COSMIC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1667
p.Y471H	SIDM01609	Endometrial Carcinoma	GDSC	NFSQYSIDP	CBL_PTK	459:467	Mutation rewiring degron network	0.2222
p.Y471H	ACH-000972	Endometrial/Uterine Cancer	CCLE	NFSQYSIDP	CBL_PTK	459:467	Mutation rewiring degron network	0.2222
p.G1573R	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.1389
p.R1281S	ACH-000744	Lung Cancer	CCLE	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1667
p.R1281S	ACH-000744	Lung Cancer	CCLE	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1667
p.R1281S	NCI-H1623	lung	COSMIC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation rewiring degron network	0.1667
p.R1281S	NCI-H1623	lung	COSMIC	AKTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1667
p.R1567G	ACH-000994	Endometrial/Uterine Cancer	CCLE	AKENG	DEG_APCC_KENBOX_2	1562:1566	Mutation rewiring degron network	0.3056
p.T1276P	ACH-002218	Leukemia	CCLE	STEATVPSP	DEG_COP1_1	1267:1275	Mutation blocking phosphorylation signal	0.75
p.T1276P	CESS	haematopoietic and lymphoid tissue	COSMIC	STEATVPSP	DEG_COP1_1	1267:1275	Mutation blocking phosphorylation signal	0.75
p.D930N	OVKATE	ovary	COSMIC	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.3056
p.D930N	ABC-1	lung	COSMIC	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.3056
p.S925A	BL-70	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1667
p.R923H	Hs-445	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.1111
p.R945Q	HCC2998	large intestine	COSMIC	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.0556
p.Y944F	HuP-T4	pancreas	COSMIC	VASSS	DEG_SPOP_SBC_1	931:935	Mutation rewiring degron network	0.0833
p.G866R	ME-1	haematopoietic and lymphoid tissue	COSMIC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.2778
p.M874I	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VASST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MICAL3

UniProt ID: Q7RTP6

Entrez ID: 57553

Protein name: [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MICAL3 in