DegronMD

Uniprot ID: Q7RTP6

Source protein: [F-actin]-monooxygenase MICAL3

Source gene: MICAL3

Class: DEG_COP1_1

Location: 1267:1275

E3 ligase: COP1

DEGRON score: 0.9764

ASA_SCORE: 91.8556

COIL: 0.9429

CONS_SCORE: 0.4191

DSS_SCORE: 0.7477

HELIX: 0.0247

FCONS_SCORE: 0.9702

RIG_SCORE: 0.5829

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1281C	TCGA-44-2657	LUAD	TCGA	STEATVPSP	DEG_COP1_1	0.1667
p.R1281C	DO233884	GACA	ICGC	STEATVPSP	DEG_COP1_1	0.1667
p.R1281C	DO25020	LUAD	ICGC	STEATVPSP	DEG_COP1_1	0.1667
p.R1281C	DO35083	PACA	ICGC	STEATVPSP	DEG_COP1_1	0.1667
p.I1260M	TCGA-77-8136	LUSC	TCGA	STEATVPSP	DEG_COP1_1	0.1389
p.I1260M	DO26593	LUSC	ICGC	STEATVPSP	DEG_COP1_1	0.1389
p.I1260M	DO228014	SKCA	ICGC	STEATVPSP	DEG_COP1_1	0.1389
p.P1259T	TCGA-CN-6997	HNSC	TCGA	STEATVPSP	DEG_COP1_1	0.1111
p.P1259T	DO14414	HNSC	ICGC	STEATVPSP	DEG_COP1_1	0.1111
p.Q1265K	TCGA-EE-A29B	SKCM	TCGA	STEATVPSP	DEG_COP1_1	0.2778
p.Q1265K	DO47255	SKCM	ICGC	STEATVPSP	DEG_COP1_1	0.2778
p.S1274F	TCGA-EE-A2MS	SKCM	TCGA	STEATVPSP	DEG_COP1_1	0.9093
p.S1274F	DO37567	SKCM	ICGC	STEATVPSP	DEG_COP1_1	0.9093
p.Q1263K	TCGA-FS-A1ZM	SKCM	TCGA	STEATVPSP	DEG_COP1_1	0.2222
p.Q1263K	DO37731	SKCM	ICGC	STEATVPSP	DEG_COP1_1	0.2222
p.P1264L	TCGA-WE-A8ZX	SKCM	TCGA	STEATVPSP	DEG_COP1_1	0.25
p.P1264L	DO51291	SKCM	ICGC	STEATVPSP	DEG_COP1_1	0.25
p.T1276I	DO228483	BRCA	ICGC	STEATVPSP	DEG_COP1_1	0.75
p.T1276I	DO52346	LUSC	ICGC	STEATVPSP	DEG_COP1_1	0.75
p.R1281H	DO229375	BTCA	ICGC	STEATVPSP	DEG_COP1_1	0.1667
p.R1281H	SIDM00168	Head and Neck Carcinoma	GDSC	STEATVPSP	DEG_COP1_1	0.1667
p.R1281H	ACH-000549	Head and Neck Cancer	CCLE	STEATVPSP	DEG_COP1_1	0.1667
p.S1262F	DO228537	MALY	ICGC	STEATVPSP	DEG_COP1_1	0.6389
p.S1262F	DO218855	SKCA	ICGC	STEATVPSP	DEG_COP1_1	0.6389
p.C1261Y	SIDM00951	T-Lymphoblastic Leukemia	GDSC	STEATVPSP	DEG_COP1_1	0.1667
p.C1261Y	ACH-002222	Leukemia	CCLE	STEATVPSP	DEG_COP1_1	0.1667
p.C1261Y	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	STEATVPSP	DEG_COP1_1	0.1667
p.R1281S	ACH-000744	Lung Cancer	CCLE	STEATVPSP	DEG_COP1_1	0.1667
p.R1281S	NCI-H1623	lung	COSMIC	STEATVPSP	DEG_COP1_1	0.1667
p.T1276P	ACH-002218	Leukemia	CCLE	STEATVPSP	DEG_COP1_1	0.75
p.T1276P	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	STEATVPSP	DEG_COP1_1	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: STEATVPSP

Degron related mutations and impact score

Drug responses associated with MICAL3 mutations

All proteins holding degron of STEATVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_COP1_1	1267:1275	STEATVPSP	COP1	0.9764	More...