DegronMD

Uniprot ID: Q7RTP6

Source protein: [F-actin]-monooxygenase MICAL3

Source gene: MICAL3

Class: DEG_SCF_FBW7_1

Location: 1452:1458

E3 ligase: FBXW7

DEGRON score: 0.9922

ASA_SCORE: 99.7286

COIL: 0.953

CONS_SCORE: 0.472

DSS_SCORE: 0.8215

HELIX: 0.0257

FCONS_SCORE: 1.0424

RIG_SCORE: 0.4886

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1442G	DO233942	GACA	ICGC	MLTPPSS	DEG_SCF_FBW7_1	0.0556
p.S1457Y	DO229257	THCA	ICGC	MLTPPSS	DEG_SCF_FBW7_1	0.712
p.P1460S	DO229242	THCA	ICGC	MLTPPSS	DEG_SCF_FBW7_1	0.2778
p.P1460S	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	MLTPPSS	DEG_SCF_FBW7_1	0.2778
p.P1460S	ACH-000980	Lung Cancer	CCLE	MLTPPSS	DEG_SCF_FBW7_1	0.2778
p.P1461T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	MLTPPSS	DEG_SCF_FBW7_1	0.25
p.T1454K	SIDM00951	T-Lymphoblastic Leukemia	GDSC	MLTPPSS	DEG_SCF_FBW7_1	0.8417
p.T1454K	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	MLTPPSS	DEG_SCF_FBW7_1	0.8417

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SCF_FBW7_1	1452:1458	MLTPPSS	FBXW7	0.9922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons