DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NFSQYSIDP
Uniprot ID:
Q7RTP6
Source protein:
[F-actin]-monooxygenase MICAL3
Source gene:
MICAL3
Class:
CBL_PTK
Location:
459:467
E3 ligase:
CBL
DEGRON score:
0.9427
ASA_SCORE:
47.7111
COIL:
0.6213
CONS_SCORE:
0.6273
DSS_SCORE:
0.3794
HELIX:
0.1848
FCONS_SCORE:
0.983
RIG_SCORE:
0.7704
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N477S
TCGA-63-A5MY
LUSC
TCGA
NFSQYSIDP
CBL_PTK
0.0556
p.N477S
DO219171
LUSC
ICGC
NFSQYSIDP
CBL_PTK
0.0556
p.R470Q
TCGA-A5-A0G2
UCEC
TCGA
NFSQYSIDP
CBL_PTK
0.25
p.R470Q
DO41235
UCEC
ICGC
NFSQYSIDP
CBL_PTK
0.25
p.N459K
TCGA-A5-A1OF
UCEC
TCGA
NFSQYSIDP
CBL_PTK
0.6918
p.N459K
DO42568
UCEC
ICGC
NFSQYSIDP
CBL_PTK
0.6918
p.D466N
TCGA-D1-A103
UCEC
TCGA
NFSQYSIDP
CBL_PTK
0.5821
p.D466N
DO42312
UCEC
ICGC
NFSQYSIDP
CBL_PTK
0.5821
p.P453H
TCGA-DA-A1I1
SKCM
TCGA
NFSQYSIDP
CBL_PTK
0.1667
p.P453H
DO37966
SKCM
ICGC
NFSQYSIDP
CBL_PTK
0.1667
p.K458N
TCGA-UY-A9PB
BLCA
TCGA
NFSQYSIDP
CBL_PTK
0.3056
p.K458N
DO219041
BLCA
ICGC
NFSQYSIDP
CBL_PTK
0.3056
p.P467T
DO229038
LICA
ICGC
NFSQYSIDP
CBL_PTK
0.7031
p.Y471H
SIDM01609
Endometrial Carcinoma
GDSC
NFSQYSIDP
CBL_PTK
0.2222
p.Y471H
ACH-000972
Endometrial/Uterine Cancer
CCLE
NFSQYSIDP
CBL_PTK
0.2222
Drug responses associated with MICAL3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NFSQYSIDP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7RTP6
[F-actin]-monooxygenase MICAL3
CBL_PTK
459:467
NFSQYSIDP
CBL
0.9427
More...
